Combined analysis of the microbiome, metabolome and transcriptome of silkie chickens in response to avian pathogenic E. coli (APEC)
文献类型： 外文期刊
作者： Li, Wenqing 1 ; Li, Wanli 2 ; Zhao, Qinghan 1 ; Wu, Pinhui 1 ; Huang, Xinmeng 1 ; Jin, Wei 4 ; Wang, Bingxun 4 ; Li, Shengli 4 ; Liu, Wei 1 ; Zhang, Guozhi 1 ; Kang, Xiangtao 2 ;
作者机构： 1.Henan Agr Univ, Coll Life Sci, Zhengzhou 450002, Peoples R China
2.Shennong Lab, Zhengzhou 450002, Henan, Peoples R China
3.Henan Agr Univ, Coll Anim Sci & Technol, Zhengzhou 450002, Peoples R China
4.Henan Acad Agr Sci, Inst Anim Sci, Zhengzhou 450002, Peoples R China
5.Henan Key Lab Farm Anim Breeding & Nutr Regulat, Zhengzhou 450002, Peoples R China
6.Henan Key Lab Innovat & Utilizat Chicken Germplasm, Zhengzhou 450002, Peoples R China
关键词： Silkie chickens; Avian pathogenic Escherichia coli; Microbiome; Metabolome; Transcriptome
期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.8； 五年影响因子：4.0 ）
ISSN： 0882-4010
年卷期： 2024 年 189 卷
页码：
收录情况： SCI
摘要： Avian colibacillosis is a bacterial disease caused by avian pathogenic Escherichia coli (APEC) that results in great losses in the poultry industry every year. Individual Silkie chickens of the same breed that are given the same feed in the same feeding conditions have different levels of resistance or susceptibility to APEC. Differences in gut microbes, gut metabolites, and gene expression in the spleen of APEC-resistant and APEC-susceptible chickens were compared, and multiple omics associations were analyzed to explore the mechanism of resistance to APEC in Silkie chickens. Compared with those in the APEC-susceptible group, the APEC-resistant group showed significantly increased abundances of many gut microorganisms, including Bacillus, Thermoactinomyces, Arthrobacter, and Ureibacillus, which were positively correlated with norvaline, L-arginine, and valyl-glycine levels. Intestinal tryptophan, indole, and indole derivative-related differentially abundant metabolites played an active role in combatting APEC infection. In the spleen, "response to stimulus" was the most significantly enriched GO term, and "cytokine-cytokine receptor interaction" was the most significantly enriched KEGG pathway. The arginine biosynthesis and PPAR signaling pathways were the KEGG pathways that were significantly enriched with differentially abundant metabolites and differentially expressed genes. This study provides new insight into the prevention and treatment of APEC infection in Silkie chickens and lays a foundation to study the mechanism of APEC infection in poultry.
- 相关文献
作者其他论文 更多>>
-
Identification of Wheat Stripe Rust Inoculum Sources and Dispersal Routes Responsible for Initial Rust Establishment in Southern Henan of China
作者：Wang, Aolin;Jiang, Ru;Zhang, Meihui;Nie, Xiao;Huang, Liang;Liu, Wei;Fan, Jieru;Zhou, Yilin;Wang, Aolin;Hu, Xiaoping;Wang, Aolin;Hu, Xiaoping;Cao, Shiqin;Sun, Zhenyu;Peng, Hong;Xu, Fei;Xu, Xiangming
关键词：aeromycology; backward-trajectory calculations; epidemiological investigation; migration routes; source identification; wheat stripe rust
-
Intestinal differential metabolite tryptophan from avian pathogenic Escherichia coli (APEC)-resistant and susceptible chickens alleviates APEC symptoms in chickens
作者：Li, Wanli;Kang, Xiangtao;Li, Wenqing;Li, Wanli;Yuan, Lin;Jin, Wei;Wang, Bingxun;Li, Shengli;Li, Guoxi;Kang, Xiangtao
关键词：Tryptophan; Avian pathogenic Escherichia coli; Chicken; Inflammation; Diet
-
Effects of luteinizing hormone receptor activation in immortalized neoplastic canine T lymphocytes
作者：Maxwell, Elizabeth;Dietz, Alexa;Li, Wanli;Li, Wanli;Li, Wanli;Kutzler, Michelle
关键词：cancer; dog; human chorionic gonadotropin; LH receptor; T -cell lymphoma
-
Development and Application of a qPCR-Based Method Coupled with Spore Trapping to Monitor Airborne Pathogens of Wheat Causing Stripe Rust, Powdery Mildew, and Fusarium Head Blight
作者：Wang, Aolin;Shang, Zhaoyue;Jiang, Ru;Zhang, Meihui;Wang, Jifeng;Li, Hongfu;Zhang, Bin;Tang, Huarong;Liu, Wei;Fan, Jieru;Zhou, Yilin;Wang, Aolin;Hu, Xiaoping;Shang, Zhaoyue;Xu, Fei;West, Jonathan S.
关键词：airborne inoculum; fungal diseases of wheat; monitoring; multiplex real-time PCR; spore quantification; spore traps
-
Multi-Omics Profiling of Lipid Variation and Regulatory Mechanisms in Poultry Breast Muscles
作者：Zhang, Hongyuan;Dai, Yaqi;Gu, Jinxing;Li, Hongtai;Wu, Ran;Jia, Jiyu;Shen, Jingqi;Han, Ruili;Sun, Guirong;Li, Wenting;Liu, Xiaojun;Li, Guoxi;Li, Wanli;Zhao, Yinli
关键词：poultry; breast Muscles; lipid Variation; transcriptome; positively selected genes
-
The Relationship of Climate Variables With the Occurrence of Fusarium pseudograminearum, an Emerging Pathogen Causing Fusarium Head Blight of Wheat in Henan Province of China
作者：Xu, Fei;Shi, Ruijie;Liu, Lulu;Li, Lijuan;Wang, Shuang;Yang, Gongqiang;Wang, Junmei;Feng, Chaohong;Song, Yuli;Xu, Fei;Shi, Ruijie;Liu, Lulu;Li, Lijuan;Wang, Shuang;Yang, Gongqiang;Wang, Junmei;Feng, Chaohong;Song, Yuli;Wang, Hongqi;Liu, Jihong;Wang, Hongqi;Liu, Jihong;Liu, Wei;Fan, Jieru;Zhou, Yilin;Xu, Xiangming
关键词：climate conditions; deoxynivalenol; Fusarium head blight (FHB);
Fusarium pseudograminearum ; wheat -
Effect of berberine on LPS-induced intestinal epithelial injury and m6A methylation in broilers
作者：Yuan, Lin;Li, Wanli;Jin, Wei;Wang, Bingxun;Li, Shengli;Wang, Haoyu;Li, Wanli;Li, Guoxi;Li, Guoxi
关键词：Broiler; Berberine; Intestinal epithelium injury; Intestinal inflammation; Methylation
