文献类型： 外文期刊
作者： Xu, Zhiyuan 1 ; Ding, Haixin 2 ; Fu, Xin 1 ; Xu, Yan 1 ; Zhu, Fadi 1 ; Ye, Huochun 1 ; Zhang, Yuan Yuan 1 ; Guo, Yongxia 3 ; Zhang, Jing 1 ; Feng, Gang 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Haikou 571101, Peoples R China
2.Inst Organ Chem, Key Lab Organ Chem, Jiangxi Sci & Technol Normal Univ, Nanchang, Peoples R China
3.Heilongjiang Bayi Agr Univ, Coll Agr, Key Lab Low carbon Green Agr Northeastern China, Minist Agr & Rural Affairs, Daqing, Peoples R China
关键词： isoquinoline-3-carboxylic acid; antibacterial activity; Acidovorax citrulli
期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：1.8； 五年影响因子：1.5 ）
ISSN： 1934-578X
年卷期： 2024 年 19 卷 2 期
页码：
收录情况： SCI
摘要： Objectives Due to the urgent need to develop innovative, environmentally sustainable bactericides, we use the natural product isoquinoline as a lead compound to discover highly active bactericides from isoquinoline derivatives.Methods In this paper, the antibacterial activity of 49 isoquinoline derivatives was evaluated against three plant bacteria in vitro.Results Among all the derivatives, isoquinoline-3-carboxylic acid (IQ3CA) demonstrated significant antibacterial activity against Ralstonia solanacearum (Rs), Acidovorax citrulli (Ac), X. oryzae pv. oryzicola (Xoc), X. campestris pv. campestris (Xcc), P. carotovorum subsp. carotovorum (Pcc), and X. fragariae (Xf), with EC50 values ranging from 8.38 to 17.35 mu g/mL. Furthermore, IQ3CA exhibited a potent protective effect against Ac, with an efficacy of 68.56% at 200 mu g/mL, which was not significantly different from that of the positive control kasugamycin (72.48%) and was superior to that of the positive control thiosen copper (64.62%). The scanning electron microscopy observations revealed that treatment of Ac cells with IQ3CA at a concentration of 25 mu g/mL resulted in a curved and sunken cell morphology, along with destroyed cell membrane integrity. Additionally, the motility and exopolysaccharides production of Ac were inhibited, and biofilm formation was prevented.Conclusion These results suggest that IQ3CA holds promise as a lead compound with antibacterial properties against plant diseases.
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