文献类型： 外文期刊

作者： Zhao, Fengyi ¹ ; Ren, Chuanying ⁴ ; Li, Lihua ⁵ ; Huang, Chao ¹ ; Zhao, Qing ⁵ ; Zhong, Yulian ¹ ; Hu, Qiaosheng ⁵ ; Liao, Wang ¹ ; Xia, Hui ¹ ; Yang, Ligang ¹ ; Wang, Shaokang ¹ ; Sun, Guiju ¹ ;

作者机构： 1.Southeast Univ, Minist Educ, Key Lab Environm Med & Engn, Nanjing, Peoples R China

2.Southeast Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing, Peoples R China

3.Nantong First Peoples Hosp, Dept Clin Nutr, Nantong, Peoples R China

4.Inst Food Proc, Heilongjiang Acad Agr Sci, Harbin, Peoples R China

5.Nanjing Med Univ, Lianshui Peoples Hosp, Kangda Coll, Huaian, Peoples R China

6.Xizang Minzu Univ, Clin Med Res Ctr Plateau Gastroenterol Dis Xizang, Xianyang, Peoples R China

7.Xizang Minzu Univ, Sch Med, Xianyang, Peoples R China

期刊名称：FOOD & FUNCTION （ 影响因子：6.1； 五年影响因子：6.5 ）

ISSN： 2042-6496

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Objective: This study aimed to observe the effects of germinated brown rice and germinated black rice on blood lipid levels, blood glucose levels and lipid metabolism-related enzymes in T2DM patients with dyslipidaemia and to study their effects on the gut microbiome and short-chain fatty acids. Methods: According to the inclusion and exclusion criteria, 68 subjects were randomly divided into a germinated brown rice group, a germinated black rice group and a white rice group. At the end of the intervention, relevant anthropometric indices, blood biochemistry, and levels of adipokines and lipid metabolism-related enzymes were measured. Faecal samples were collected for 16S rDNA high-throughput sequencing and for an analysis of short-chain fatty acids. Results: After 3 months of intervention with germinated brown rice, germinated black rice or white rice, 21 people in each group completed the intervention as required. At the end of the intervention, the levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the germinated brown rice group and germinated black rice group were significantly lower than those in the white rice group. The levels of adiponectin (ADPN) and lecithin cholesterol acyltransferase (LCAT) in the germinated brown rice group were significantly higher than those in the white rice group (P < 0.05). At the genus level, interventions with germinated brown rice and germinated black rice significantly increased the relative abundance of Megamonas, Muribaculaceae and Alloprevotella and significantly decreased the relative abundance of Veillonella (P < 0.05). After 3 months of intervention, a significant decrease in waist circumference was observed within the germinated brown rice group compared to that at baseline (P < 0.05). Conclusions: Compared with the consumption of white rice, the consumption of germinated brown rice and germinated black rice can effectively regulate the glucose and lipid metabolism of this population. In addition, interventions involving the use of germinated brown rice and germinated black rice may further improve intestinal diversity and abundance, increase the relative abundance of Megamonas and decrease the relative abundance of Veillonella.