文献类型： 外文期刊
作者： Li, Jing 1 ; Zhang, Wen 4 ; Xu, Hongwei 1 ; Zhou, Longhua 1 ; Guo, Huimin 1 ; Zhang, Shuwei 1 ; Lu, Ruiju 1 ; Liang, Xiao 5 ; Chang, Mengling 1 ; Liu, Chenghong 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Shanghai Key Lab Agr Genet & Breeding, Shanghai, Peoples R China
2.Shanghai Baixin Biotechnol Co Ltd, Shanghai, Peoples R China
3.Shanghai Univ Med & Hlth Sci, Coll Publ Hlth, Shanghai, Peoples R China
4.Fudan Univ, Zhongshan Hosp, Dept Integrat Med, Shanghai, Peoples R China
5.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai, Peoples R China
期刊名称：NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL （ 影响因子：2.816； 五年影响因子：3.095 ）
ISSN： 0163-5581
年卷期：
页码：
收录情况： SCI
摘要： Barley (Hordeum vulgare L.) grass has been recognized as a functional food with a wide spectrum of health-promoting properties. Supplementation with barley grass has the potential to prevent chronic diseases, such as cancer. Here, we investigated whether barley grass could protect against hepatocellular carcinoma (HCC). Our data showed that administration of barley grass juice attenuates tumor development in a hydrodynamic gene delivery-induced model of HCC. The expression levels of the immune cell markers Ptprc and Adgre1 were upregulated in the barley grass juice-treated and normal groups, compared to those in the vehicle group in the HCC model. Immune cells (CD45+, F4/80+, and CLEC4F + iNOS + cells) infiltration in the liver increased following barley grass juice administration. Our results indicate that barley grass could be beneficial for HCC alleviation, partly by regulating immune cell infiltration. The ingredients of barley grass affect immune cell infiltration in HCC, and the detailed mechanism requires further study.
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