文献类型： 外文期刊

作者： Shi, Peizheng ¹ ; Ye, Chen ² ; Sun, Zhuang ² ; Sun, Kaiqiang ² ; Zhao, Ningbin ² ; Pourfakhr, Mahan ⁵ ; Cai, Tao ³ ; Nishimura, Kazuhito ³ ; Jiang, Nan ³ ; Tsai, Hsu-Sheng ⁶ ; Wu, Lidong ⁷ ; Wu, Wenqi ⁸ ; Yu, Jiancheng ¹⁰ ; Fu, Li ¹³ ; Xu, Lixin ¹ ; Chen, Jun ⁵ ; Lin, Cheng-Te ⁴ ;

作者机构： 1.Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Peoples R China

2.Qianwan Inst CNITECH, Ningbo 315336, Peoples R China

3.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, State Key Lab Adv Marine Mat, Ningbo 315201, Peoples R China

4.Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China

5.Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

6.Harbin Inst Technol, Sch Phys, Harbin 150001, Peoples R China

7.Chinese Acad Fishery Sci, Key Lab Control Qual & Safety Aquat Prod, Beijing 100141, Peoples R China

8.Guangzhou Med Univ, Affiliated Hosp 2, Dept Urol, Guangzhou 510260, Guangdong, Peoples R China

9.Guangzhou Med Univ, Affiliated Hosp 1, Guangdong Key Lab Urol, Guangzhou 511495, Guangdong, Peoples R China

10.Ningbo Univ, Inst Mass Spectrometry, Zhejiang Engn Res Ctr Adv Mass Spectrometry & Clin, Ningbo 315211, Peoples R China

11.Zhenhai Inst Mass Spectrometry, Ningbo 315211, Peoples R China

12.Ningbo Univ, Fac Elect Engn & Comp Sci, Ningbo 315211, Peoples R China

13.Hangzhou Dianzi Univ, Coll Mat & Environm Engn, Hangzhou 310018, Peoples R China

关键词： Electrochemical biosensors; Oxalic acid; Point-of-care testing; Biomonitoring

期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：10.5； 五年影响因子：10.1 ）

ISSN： 0956-5663

年卷期： 2025 年 285 卷

页码：

收录情况： SCI

摘要： The binding of oxalic acid (OA) with metal ions, particularly calcium ions, is a key factor in kidney stone formation, as it produces insoluble calcium oxalate, which crystallizes and accumulates in the kidneys. Consequently, OA in urine is commonly considered a significant biomarker for clinical diagnosis and early screening of kidney stones. This study reports churros-like V2Se9 nanostructures synthesized using a solvothermal method (high pressure and temperature) for sensitive and selective electrochemical detection of OA in urine. The electrodes made of churros-like V2Se9 hybridized with reduced graphene oxide (rGO) for OA recognition, demonstrated a linear range from 20 nM to 4 mM, with an extremely low detection limit of 9.7 nM. To enable fast, user friendly, and accurate point-of-care testing (POCT) for OA in urine samples, we designed and developed a portable workstation integrated with smartphone for data visualization. This is the first study to utilize the V2Se9 system for highly sensitive biosensor applications, highlighting its potential to advance screening techniques for key indicators of kidney stones by incorporating novel transition metal chalcogenide nanomaterials in POCT devices.