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A meta-analysis: Effect of androgens on reproduction in sows

文献类型： 外文期刊

作者： Guo, Zhenhua 1 ; Lv, Lei 2 ; Liu, Di 1 ; Ma, Hong 1 ; Radovic, Cedomir 4 ;

作者机构： 1.Heilongjiang Acad Agr Sci, Inst Anim Husb, Key Lab Combining Farming & Anim Husb, Minist Agr & Rural Affairs, Harbin, Peoples R China

2.Heilongjiang Acad Forestry, Wood Sci Res Inst, Harbin, Peoples R China

3.Harbin Univ, Harbin, Peoples R China

4.Inst Anim Husb, Dept Pig Breeding & Genet, Belgrade, Serbia

关键词： dihydrotestosterone; oocyte; ovulation; swine; testosterone

期刊名称：FRONTIERS IN ENDOCRINOLOGY （ 影响因子：5.2； 五年影响因子：5.9 ）

ISSN： 1664-2392

年卷期： 2023 年 14 卷

页码：

收录情况： SCI

摘要： Introduction The mechanisms by which male hormones affect the development of ovaries and follicles has been studied by injecting exogenous androgens into sows. This may provide a reference for human polycystic ovary syndrome (PCOS), and can also provide guidance for improving the litter size of sows.Methods We present a meta-analysis of studies published in the past 30 years on the effect of androgens on the ovulation rate of sows. A total of 517 papers were analyzed.Results The results showed that both testosterone (T) and dihydrotestosterone (DHT) injected into sows were positively related to the ovulation rate. T did not have a relevant effect on swine in vivo blastocyst survival rate. DHT had a negative phase with respect to blastocyst survival rate. Pig T-androgen receiver affinity was higher than the analogous affinity for DHT; this is different in humans. This suggests that sows are not suitable as human PCOS experimental animal models.Discussion To improve the litter size of sows, future research should focus on the mixed use of T and DHT, and the timing of use should be consistent with the periodic changes in androgen levels in sows. In addition, the welfare of experimental sows should be considered with reference to the clinical symptoms of PCOS. In the figure, OR stands for ovulation rate. The initial purpose of this study was to determine whether androgens affect sow reproduction in swine. The meta-analysis results showed that testosterone (T) and dihydrotestosterone (DHT) are positively correlated with swine OR. T and DHT play different roles in regulating sow reproduction. This leads us to conclude that androgens affect pigs differently from humans. Then, T/DHT docking to androgen receptor binding affinity was compared. The findings were also different from those of human affinities. Finally, the following conclusions were drawn: in research on human PCOS, selecting pigs as animal models is not suitable, and to improve the litter sizes of sows, future research should focus on the mixed use of T and DHT.

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