Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota
文献类型： 外文期刊
作者： Chen, Lin 1 ; Jiang, Qihong 2 ; Jiang, Chenkai 1 ; Lu, Hongling 1 ; Hu, Wenjun 1 ; Yu, Shaofang 1 ; Li, Mingqian 3 ; Tan, Chin Ping 4 ; Feng, Yongcai 5 ; Xiang, Xingwei 2 ; Shen, Guoxin 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Sericulture & Tea, Hangzhou 310021, Zhejiang, Peoples R China
2.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Zhejiang, Peoples R China
3.Zhejiang Acad Tradit Chinese Med, Tongde Hosp Zhejiang Prov, Canc Inst Integrated Tradit Chinese & Western Med, Hangzhou 310012, Zhejiang, Peoples R China
4.Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Technol, Serdang 43400, Malaysia
5.Xujing Hangzhou Biotechnol Res Inst Co Ltd, Hangzhou 310021, Zhejiang, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：6.1； 五年影响因子：6.5 ）
ISSN： 2042-6496
年卷期： 2023 年 14 卷 6 期
页码：
收录情况： SCI
摘要： Obesity has been reported to be associated with dysbiosis of gut microbiota. Sciadonic acid (SC) is one of the main functional components of Torreya grandis "Merrillii" seed oil. However, the effect of SC on high-fat diet (HFD)-induced obesity has not been elucidated. In this study, we evaluated the effects of SC on lipid metabolism and the gut flora in mice fed with a high-fat diet. The results revealed that SC activates the PPAR alpha/SREBP-1C/FAS signaling pathway and reduces the levels of total cholesterol (TC), triacylglycerols (TG), and low-density lipoprotein cholesterol (LDL-C), but increases the level of high-density lipoprotein cholesterol (HDL-C) and inhibits weight gain. Among them, high-dose SC was the most effective; the TC, TG and LDL-C levels were reduced by 20.03%, 28.40% and 22.07%, respectively; the HDL-C level was increased by 8.55%. In addition, SC significantly increased glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels by 98.21% and 35.17%, respectively, decreased oxidative stress, and ameliorated the pathological damage to the liver caused by a high-fat diet. Furthermore, SC treatment altered the composition of the intestinal flora, promoting the relative abundance of beneficial bacteria such as Lactobacillus and Bifidobacterium, while simultaneously decreasing the relative abundance of potentially harmful bacteria such as Faecalibaculum, norank_f_Desulfovibrionaceae, and Romboutsia. Spearman's correlation analysis indicated that the gut microbiota was associated with SCFAs and biochemical indicators. In summary, our results suggested that SC can improve lipid metabolism disorders and regulate the gut microbial structure.
- 相关文献
作者其他论文 更多>>
-
Creating Climate-Resilient Crops by Increasing Drought, Heat, and Salt Tolerance
作者：Sugumar, Tharanya;Smith, Jennifer;Zhang, Hong;Shen, Guoxin
关键词：abiotic stress; drought; food security; heat; salinity; climate change
-
Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice
作者：Yao, Shiwei;Xiang, Xingwei;Yao, Shiwei;Lu, Hongling;Jiang, Qihong;Jiang, Chenkai;Hu, Wenjun;Shen, Guoxin;Chen, Lin;Yao, Shiwei;Xiang, Xingwei;Zhou, Tianhuan;Du, Qun;Li, Mingqian;Tan, Chin Ping;Tan, Chin Ping;Feng, Yongcai
关键词：
-
Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye
作者：Jiang, Qihong;Wang, Rui;Liu, Shulai;Xiang, Xingwei;Jiang, Qihong;Wang, Rui;Liu, Shulai;Xiang, Xingwei;Jiang, Qihong;Wang, Rui;Liu, Shulai;Xiang, Xingwei;Chen, Lin;Shen, Guoxin;Chen, Yin;Deng, Shanggui
关键词：Tegillarca granosa polysaccharide; Type 2 diabetes mellitus; Glycolipid metabolism; PI3K/Akt signaling pathway
-
Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoprotein
作者：Yao, Shiwei;Chen, Hui;Xiang, Xingwei;Zhou, Yufang;Yao, Shiwei;Chen, Hui;Xiang, Xingwei;Yao, Shiwei;Chen, Hui;Xiang, Xingwei;Yao, Shiwei;Chen, Hui;Xiang, Xingwei;Chen, Lin;Zhong, Yaqi;Cai, Yijing;Zhou, Yufang
关键词：Thunnus albacares eggs yolk glycoprotein; Lipid metabolism; Gut microbiota; Obesity; Hyperlipidemia
-
Exploring the Regulatory Effect of Tegillarca granosa Polysaccharide on High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice Based on Intestinal Flora
作者：Yang, Xingwen;Yao, Shiwei;Jiang, Qihong;Chen, Hui;Liu, Shulai;Xiang, Xingwei;Yang, Xingwen;Yao, Shiwei;Jiang, Qihong;Chen, Hui;Liu, Shulai;Xiang, Xingwei;Yang, Xingwen;Yao, Shiwei;Jiang, Qihong;Chen, Hui;Liu, Shulai;Xiang, Xingwei;Shen, Guoxin;Chen, Lin
关键词：AMPK signaling; high-fat diet; intestinal flora; lipid metabolism; non-alcoholic fatty liver; Tegillarca granosa polysaccharide
-
Sciadonic acid ameliorates cyclophosphamide-induced immunosuppression by modulating the immune response and altering the gut microbiota
作者：Chen, Lin;Jiang, Qihong;Jiang, Chenkai;Lu, Hongling;Hu, Wenjun;Yu, Shaofang;Shen, Guoxin;Yao, Shiwei;Xiang, Xingwei;Li, Mingqian;Feng, Yongcai;Tan, Chin Ping
关键词：cyclophosphamide; gut microbiota; immunomodulatory activity; intestinal barrier; sciadonic acid
-
Bioenzyme-nanoenzyme-chromogen all-in-one test strip for convenient and sensitive detection of malathion in water environment
作者：Zhang, Hanwen;Wang, Xini;Xiang, Xingwei;Jin, Jiabin;Han, Wei;Liu, Zhenjiang;Chen, Lin;Qin, Lei;Mao, Xiaoyan
关键词：Alkaline phosphatase; Malathion; Test strip; Rapid testing
