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Diverse Galactooligosaccharides Differentially Reduce LPS-Induced Inflammation in Macrophages

文献类型： 外文期刊

作者： Sun, Congcong 1 ; Hao, Bifang 2 ; Pang, Daorui 1 ; Li, Qian 1 ; Li, Erna 1 ; Yang, Qiong 1 ; Zou, Yuxiao 1 ; Liao, Sentai 1 ; Liu, Fan 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Sericultural & Agri Food Res Inst, Key Lab Funct Foods, Guangdong Key Lab Agr Prod Proc,Minist Agr & Rural, Guangzhou 510600, Peoples R China

2.Jiangsu Univ Sci & Technol, Sch Biotechnol, Zhenjiang 212018, Peoples R China

关键词： galactooligosaccharide; RAW264; 7 cells; lipopolysaccharide (LPS); anti-inflammatory activity; TLR4/NF-kappa B signaling pathway

期刊名称：FOODS （ 影响因子：5.561； 五年影响因子：5.94 ）

ISSN：

年卷期： 2022 年 11 卷 24 期

页码：

收录情况： SCI

摘要： The effects of natural and synthetic galactooligosaccharides (GOS) on inflammation were explored by investigating the structure-activity relationship between the degree of GOS polymerization and in vitro anti-inflammatory activity, together with the potential underlying mechanism of their anti-inflammatory effects. The results demonstrated that GOS had strong anti-inflammatory effects in lipopolysaccharide (LPS)-induced RAW264.7 macrophages, including the inhibition of nitric oxide production and the reduced expression of pro-inflammatory mediators (interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha), induced nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), and proteins related to the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-kappa B signaling pathway. GOS4, which has the highest degree of polymerization, exerted the strongest anti-inflammatory activity among the GOS examined. More importantly, our findings confirmed the anti-inflammatory effects of GOS on RAW264.7 macrophages via the TLR4/NF-kappa B pathway. Our experimental results could provide further support for the exploration of GOS in human nutrition and health.

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