An effective restoration of one-carbon metabolism in folate-deficient mice with a high-folate corn inbred line
文献类型： 外文期刊
作者： Lu, Xiaolin 1 ; Jiang, Ling 2 ; Zhang, Qizong 3 ; Huo, Junshen 4 ; Min, Jie 1 ; Liang, Qiuju 2 ; Zhao, Lijiao 3 ; Li, Yan 4 ; Chang, Shaoyan 1 ; Zhang, Ting 1 ; Zhang, Chunyi 2 ; Wang, Li 1 ;
作者机构： 1.Capital Inst Pediat, Municipal Key Lab Child Dev & Nutri, Beijing, Peoples R China
2.Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing, Peoples R China
3.Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
4.Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing, Peoples R China
5.Hainan Acad Agr Sci, Sanya Inst, Sanya, Peoples R China
关键词： Folic Acid (FA); DNA Methylation; High-Folate Corn; Long Interspersed Nucleotide Element-1 (LINE-1); Lipid Metabolism
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.223； 五年影响因子：5.178 ）
ISSN： 1756-4646
年卷期： 2022 年 99 卷
页码：
收录情况： SCI
摘要： Since folic acid (FA) was officially recommended in 1998, concerns have emerged about the effect of excess FA intake, in particular with respect to negative clinical effects. Given this, a high-folate corn inbred line that we identified from a global germplasm collection was believed to become a valid alternative to FA supplementation. In this study, we proved this natural form of plant-sourced folates exhibited an effective restoration of folate deficiency. Folate metabolism and methylation modifications were restored in folate-deficient mice with folate-supplemented diets in 4 weeks. Restoration effects varies depending on folate sources, restricted retrotransposon activity and an orderly pattern of phospholipid/lipid metabolism protected by this high-folate corn partly en-sures a healthy folate status for development. Totally, we proved in mice models that this kind of folate bio-fortification corn could provide a valid alternation of FA supplementation in alleviation of folate deficiency during pregnancy.
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