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A broad host phage, CP6, for combating multidrug-resistant Campylobacter prevalent in poultry meat

文献类型： 外文期刊

作者： Zhang, Xiaoyan 1 ; Tang, Mengjun 1 ; Zhou, Qian 1 ; Lu, Junxian 1 ; Zhang, Hui 2 ; Tang, Xiujun 1 ; Ma, Lina 1 ; Zhang, Jing 1 ; Chen, Dawei 1 ; Gao, Yushi 1 ;

作者机构： 1.Minist Agr, Jiangsu Inst Poultry Sci, Supervis Inspect & Testing Ctr Poultry Qual Yangzh, Yangzhou 225125, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Nanjing 210014, Jiangsu, Peoples R China

关键词： Campylobacter; lytic phage; poultry meat; food safety

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 4 期

页码：

收录情况： SCI

摘要： Campylobacter is a major cause of bacterial foodborne diarrhea worldwide. Consumption of raw or undercooked chicken meat contaminated with Campylobacter is the most common causative agent of human infections. Given the high prevalence of contamination in poultry meat and the recent rise of multi -drug -resistant (MDR) Campylobacter strains, an effective intervention method of reducing bird colonization is needed. In this study, the Campylobacter-specific lytic phage CP6 was isolated from chicken feces. Phage CP6 exhibited a broad host range against different MDR Campylobacter isolates (97.4% of strains were infected). Some biological characteristics were observed, such as a good pH (3-9) stability and moderate temperature tolerance (<50 degree celsius). The com plete genome sequence revealed a linear double -stranded DNA (178,350 bp, group II Campylobacter phage) with 27.51% GC content, including 209 predicted open reading frames, among which only 54 were annotated with known functions. Phylogenetic analysis of the phage major capsid protein demonstrated that phage CP6 was closely related to Campylobacter phage CPt10, CP21, CP20, IBB35, and CP220. CP6 phage exerted good antimicrobial effects on MDR Campylobacter in vitro culture and reduced CFUs of the host cells by up to 1 -log compared with the control in artificially contaminated chicken breast meat. Our findings suggested the potential of CP6 phage as a promising antimicrobial agent for combating MDR Campylobacter in food processing.

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