Hormone effects of eighteen bisphenol analogues and their effects on cellular homeostasis and the typical signal pathways
文献类型： 外文期刊
作者： Ma, Mengmeng 1 ; Guo, Dongmei 2 ; Wang, Ruiguo 1 ; Wang, Peilong 1 ; Su, Xiaoou 1 ;
作者机构： 1.Chinese Acad Agr Sci, Minist Agr, Key Lab Agroprod Qual & Safety, Inst Qual Stand & Testing Technol Agroprod, 12 Zhong Guan Cun South St, Beijing 100081, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou 310021, Zhejiang, Peoples R China
3.Beijing Jingwa Agr Sci & Technol Innovat Ctr, 1 Yuda Rd, Beijing 101206, Peoples R China
关键词： Hormone effect; Bisphenol analogues; MDA-kb2; MCF-7 cells; Signal pathway; Cellular homeostasis
期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.9； 五年影响因子：9.5 ）
ISSN： 0269-7491
年卷期： 2023 年 338 卷
页码：
收录情况： SCI
摘要： Through the transfer chain of surroundings from feed to the farmed-animals and ultimately the corresponding livestock and poultry products, people are exposed to large amounts of bisphenol analogues (BPs), such as rational emissions from manufacturing plants, feed packaging bags and food packaging contact. Some BPs have been reported to show certain toxicological effects, especially, estrogen and endocrine disrupting effect. With the increasing application of BPs, the problem is becoming more and more serious. We systematically studied the hormonal effects of 18 BPs and their effects on cell homeostasis and classical signaling pathways by using classical E-SCREEN assay, fluorescent probes and western blotting. The results confirmed the estrogen-like effect of 13 BPs and 6 BPs obtained high docking scores (Scores < -9.0) for the three receptors simultaneously with the main interactions of hydrophobic, hydrogen and pi-stacking of T-type bonds. BPAP regulates cells via apoptosis and steroid signaling pathway by intracellular ROS and mitochondrial followed the caspase pathway. BPE and BPS were involved in the classical NF-kappa B and Hippo signaling pathways. All data provides scientific basis for the safety risk assessment of endocrine disrupting and cellular homeostasis evaluation of BPs as chronic environmental pollution.
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