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Protective effects of polysaccharide from Artocarpus heterophyllus Lam. (jackfruit) pulp on non-alcoholic fatty liver disease in high-fat diet rats via PPAR and AMPK signaling pathways

文献类型： 外文期刊

作者： Zeng, Shunjiang 1 ; Chen, Yuzi 1 ; Wei, Chenxi 1 ; Tan, Lehe 1 ; Li, Chuan 2 ; Zhang, Yanjun 1 ; Xu, Fei 1 ; Zhu, Kexue 1 ; Wu, Gang 1 ; Cao, Jun 2 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Spice & Beverage Res Inst, Wanning 571533, Hainan, Peoples R China

2.Hainan Univ, Coll Food Sci & Engn, Haikou 570228, Hainan, Peoples R China

3.Hua Zhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei, Peoples R China

4.Jilin Agr Univ, Coll Food Sci & Engn, Changchun 130118, Jilin, Peoples R China

5.Key Lab Proc Suitabil & Qual Control Special Trop, Wanning 571533, Hainan, Peoples R China

关键词： Artocarpus heterophyllus Lam; polysaccharide; Liver function; Non-alcoholic fatty liver disease; Signaling pathways

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.223； 五年影响因子：5.178 ）

ISSN： 1756-4646

年卷期： 2022 年 95 卷

页码：

收录情况： SCI

摘要： A polysaccharide from jackfruit pulp (JFP-Ps) has been found to exhibit various types of bioactivities. This study aimed to investigate the effects and potential mechanisms of JFP-Ps on non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet in rats. The pathological changes in the liver and liver function were determined using hematoxylin-eosin staining and biochemical analysis. RT-qPCR and Western blots were employed to study the expression of proteins associated with lipid metabolism and proinflammatory cytokines. Results showed that JFP-Ps reduced liver weight and liver index, and influenced liver function in high-fat diet rats. Furthermore, JFP-Ps up-regulated the lipolytic genes (PPAR alpha, LPL, CPT1, HSL) expression, downregulated the expression of lipogenic genes (SREBP-1c, ACC, FAS) and proinflammatory cytokines (TNF-alpha, IL-6) genes. JFP-Ps increased the protein expression of p-AMPK, and decreased the protein expression of SREBP-1c and AMPK. These results revealed that JFP-Ps might improve liver function and alleviate NAFLD through activating PPAR and AMPK signaling pathways.

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