808 nm NIR-triggered Camellia sapogein/curcumin-based antibacterial upconversion nanoparticles for synergistic photodynamic-chemical combined therapy
文献类型： 外文期刊
作者： Liu, Ze-Yu 1 ; Tang, Xiao-Yue 1 ; Huang, Chuan-Qing 1 ; Zhang, Jin 1 ; Huang, Wen-Qian 2 ; Ye, Yong 1 ;
作者机构： 1.South China Univ Technol, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Guangzhou 510641, Peoples R China
2.Guangdong Acad Agr Sci, Sericulture & Agrifood Res Inst, Minist Agr & Rural Affairs, Key Lab Funct Foods,Guangdong Key Lab Agr Prod Pr, Guangzhou 510610, Peoples R China
3.Jiangxi Environm Engn Vocat Coll, Ganzhou 341000, Peoples R China
期刊名称：INORGANIC CHEMISTRY FRONTIERS （ 影响因子：7.779； 五年影响因子：7.154 ）
ISSN： 2052-1553
年卷期： 2022 年 9 卷 8 期
页码：
收录情况： SCI
摘要： Antibacterial upconversion nanoparticles (UCNP)-based photodynamic-chemical combined therapy (UCNP-aPCCT) provides an ideal method to solve the problem of antibiotic-resistant bacteria in deep-tissue infections. Saponin is a kind of natural product exhibiting promising antibacterial activity. Curcumin is also a natural product that could be used as photosensitizer for antibacterial photodynamic therapy (aPDT). Herein, we have designed the dual-layer silica-coated upconversion nanoparticles combined with UCNP-photodynamic therapy (PDT) and chemotherapy using curcumin as a photosensitizer and the Camellia sapogenin derivative (CSD) as an antibacterial agent. It turned out that the prepared UCNP@mSiO(2)(Cur)@DmSiO(2)(CSD)@PVP nanoparticles displayed high antibacterial activity against Escherichia coli and Staphylococcus aureus under near-infrared (NIR) irradiation at 808 nm. Its antibacterial activity is stronger than that of the simple sum of saponin and curcumin aPDT, indicating the existence of a synergetic photodynamic-chemical effect. The current nanoparticle drug system may have potential applications for deep-tissue anti-infection treatment.
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