Modulation of fecal microbiota and reductions in fecal antibiotic resistance genes (ARGs) driven by Weissella-fermented feed in growing pigs
文献类型： 外文期刊
作者： Zhang, Dongyan 1 ; Ji, Haifeng 1 ; Wang, Sixin 1 ; Liu, Ming 2 ; Chen, Meixia 1 ; Liu, Hui 1 ;
作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Sci & Vet Med, Beijing 100097, Peoples R China
2.Beijing Univ Agr, Anim Sci & Technol Coll, Beijing 100096, Peoples R China
关键词： Probiotics fermentation; Pig farming; Microbiota; ARGs; Molecular docking
期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.1； 五年影响因子：6.4 ）
ISSN： 0147-6513
年卷期： 2024 年 285 卷
页码：
收录情况： SCI
摘要： Probiotics-induced feed fermentation can improve the composition of microbiota, leading to benefits in pig production. However, the influence of probiotics-driven feed fermentation on pollution reduction is limited. This study aimed to analyze the impact of Weissella-based-based feed fermentation on the chemical characteristics, changes in microbial abundance, and antibiotic resistance genes (ARGs). Moreover, the possible mechanism and the association among them was also analyzed. First, pigs reared on fermented feed exhibited improved growth performance. The fermentation group showed a significant reduction in emissions of total phosphorus (TP), total carbon (TC), organic matter (OM), copper (Cu), and zinc (Zn) levels in feces compared to the control group. The fermentation group also showed a significant decrease in the ARGs, especially for the tetX, , tetW, , tetQ, , tetL, , tetO, , tet32, , tet44, , ermG, , ermF, , CfxA2, , CfxA3, , aph3-III,- III , aadA, , and ant9-I, compared to the control group. The primary functional microbiota, characterized by increased levels of Bifidobacterium, Megasphaera, , and Mitsuokella, , and decreased levels of Methanosphaera, and Ruminiclostridium, , displayed both negative and positive correlations with ARGs, TC, TP, OM, Cu, and Zn. Furthermore, a significant association was observed between the alterations in microbiota and ARGs and the lactic acid concentration in the fermented feed. The molecular docking results showed a good fit between lactate dehydrogenase and three antibiotics, particularly tetracycline. In conclusion, these results offer novel targets and strategies to address environmental pollutants associated with pig farming.
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