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Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs

文献类型： 外文期刊

作者： Ouyang, Kun 1 ; Chen, Ting 2 ; Sun, Ruiping 1 ; Xie, Yali 1 ; Qi, Qi 1 ; Li, Xiang 1 ; Liu, Jie 1 ; Liu, Quanwei 1 ; Wei, Limin 1 ;

作者机构： 1.Hainan Acad Agr Sci, Inst Anim Husb & Vet Res, Hainan Key Lab Trop Anim Breeding & Epidem Res, Haikou, Peoples R China

2.South China Agr Univ, Coll Anim Sci, Guangzhou, Peoples R China

3.Hainan Acad Agr Sci, Sanya Inst, Hainan Expt Anim Res Ctr, Sanya, Peoples R China

关键词： nursery Hainan piglet; cecropin; growth performance; diarrhea rate; gut health

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）

ISSN：

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： Antimicrobial peptides could inhibit the growth of harmful bacteria and promote the growth performance in weaned piglets. Here, we investigated the effects of dietary supplementation with cecropin antimicrobial peptides (CAP) on growth performance, diarrhea rate, intestinal health in nursery Hainan piglets. For this, 120 healthy nursery Hainan male piglets (13.29 +/- 0.29 kg, 44 days old) were randomly divided into 5 groups-a control (CON) group (fed a basal diet), an antibiotic control (AC) group (fed a basal diet supplemented with 250 mg/kg colistin sulfate); and 3 experimental groups (provided the basal diet supplemented with 250, 500, or 1,000 mg/kg CAP). Pre-feeding lasted 7 days and the official period lasted 40 days. The results showed that compared with the CON group, dietary supplementation of 500 mg/kg CAP had significantly increased the average daily gain (ADG, p < 0.05), while the feed conversion ratio (FCR) and diarrhea rate were markedly reduced (p < 0.05), serum total protein (TP), albumin, IgA, IgM, and globulin concentrations were significantly increased (p < 0.05), where serum aspartate aminotransferase (AST) level was significantly reduced (p < 0.05), and it also increased the villus height and the villus height-to-crypt depth ratio in the jejunum, reduced the serum D-lactic acid concentrations and diamine oxidase activity, and increased the expression level of ZO-1 and occludin in the jejunum and ileum (p < 0.05), the relative abundance of Firmicutes, Lactobacillus, and Limoslactobacillus in the colon were increased (p < 0.05), whereas that of Streptococcus and Escherichia-Shigella were reduced (p < 0.05). These results indicated that dietary supplementation with 500 mg/kg CAP could improve the growth performance, reduce the diarrhea rate, improve the serum immunity, intestinal health of nursery pigs.

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