Study on the synergistic protective effect of Lycium barbarum L. polysaccharides and zinc sulfate on chronic alcoholic liver injury in rats
文献类型： 外文期刊
作者： Yan, Yamei 1 ; Wu, Wanqiang 2 ; Lu, Lu 1 ; Ren, Jie 2 ; Mi, Jia 1 ; Liu, Xuebo 2 ; Cao, Youlong 1 ;
作者机构： 1.Natl Wolfberry Engn Res Ctr, Yinchuan 750002, Peoples R China
2.Northwest A&F Univ, Coll Food Sci & Engn, 28 Xi Nong Rd, Yangling 712100, Shaanxi, Peoples R China
关键词： alcoholic liver injury; Lycium barbarum L; polysaccharides; synergistic effects; ZnSO4
期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：3.553； 五年影响因子：3.634 ）
ISSN： 2048-7177
年卷期： 2019 年 7 卷 11 期
页码：
收录情况： SCI
摘要： Both Lycium barbarum L. polysaccharides (LBP) and zinc have protective effects on liver injuries. In this paper, LBP and ZnSO4 were combined to study the effects on the prevention of alcoholic liver injury. The rats were divided into six groups, the normal group, alcohol group, zinc sulfate group, LBP group, low-dose group of ZnSO4, and high-dose group of ZnSO4 and LBP, used to explore the impact of LBP and ZnSO4 complex on liver lipid metabolism of alcohol, alcohol-metabolizing enzymes, oxidative damage, and inflammation of the liver. The experimental model was established by gavage treatment, observation, and determination of indexes of rats. The results showed that the combination of LBP and ZnSO4 could significantly decrease the levels of triglyceride (TG), total cholesterol (TC), tumor necrosis factor-alpha(TNF-& x251;), malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and the activity of enzyme subtype 2E1 (CYP2E1). It also significantly increased the activities of total superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione peptide (GSH), and alcohol dehydrogenase, effectively improved the liver tissue lesion. What is more, the combination of LBP and ZnSO4 had a synergistic effect on the remission of alcoholic fatty liver, and alleviated chronic alcoholic liver injury by promoting lipid metabolism, inhibiting oxidative stress, controlling inflammatory responses, and regulating the expression and activity of alcohol-metabolizing enzymes in rats.
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