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Stereoisomers of octahydrocurcumin, the hydrogenated metabolites of curcumin, display stereoselective activity on the CYP2E1 enzyme in L-02 cells

文献类型： 外文期刊

作者： Luo, Dandan 1 ; Lin, Yinsi 2 ; Chen, Jiannan 2 ; Huang, Xiaoqi 2 ; Xie, Youliang 2 ; Liu, Yuhong 2 ; Ni, Suiqin 1 ; Su, Ziren 2 ; Li, Yucui 2 ; Zhang, Zhenbiao 3 ;

作者机构： 1.South China Univ Technol, Guangzhou Peoples Hosp 1, Dept Clin Pharm, Guangzhou 510180, Peoples R China

2.Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

3.Tea Res Inst, Guangdong Acad Agr Sci, Guangdong Key Lab Tea Resources Innovat & Utilizat, Guangzhou 510640, Peoples R China

期刊名称：FOOD & FUNCTION （ 影响因子：6.1； 五年影响因子：6.5 ）

ISSN： 2042-6496

年卷期： 2023 年 14 卷 6 期

页码：

收录情况： SCI

摘要： As the final hydrogenated metabolite of curcumin, octahydrocurcumin (OHC) exhibits increased powerful bioactivities. The chiral and symmetric chemical structure indicated that there were two OHC stereoisomers, (3R,5S)-octahydrocurcumin (Meso-OHC) and (3S,5S)-octahydrocurcumin ((3S,5S)-OHC), which may induce different effects on metabolic enzymes and bioactivities. Thus, we detected OHC stereoisomers from rat metabolites (blood, liver, urine and feces) after oral administration of curcumin. In addition, OHC stereoisomers were prepared and then their different influences on cytochrome P450 enzymes (CYPs) and UDP-glucuronyltransferases (UGTs) in L-02 cells were tested to explore the potential interaction and different bioactivities. Our results proved that curcumin could be metabolised into OHC stereoisomers first. In addition, Meso-OHC and (3S,5S)-OHC exhibited slight induction or inhibition effects on CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP3A4 and UGTs. Furthermore, Meso-OHC exhibited more intensive inhibition toward CYP2E1 expression than (3S,5S)-OHC, ascribed to the different mode of binding to the enzyme protein (P < 0.05), which finally induced more effective liver protection effects in acetaminophen-induced L-02 cell injury.

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