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LmFKBP24 interacts with LmEaster to inhibit the antifungal immunity of Locusta migratoria

文献类型： 外文期刊

作者： Zhang, Neng 1 ; Feng, Shiqian 1 ; Duan, Saiya 1 ; Yin, Yiting 1 ; Ullah, Hidayat 3 ; Li, Hongmei 4 ; Davaasambuu, Undarmaa 5 ; Wei, Shuhua 6 ; Nong, Xiangqun 1 ; Zhang, Zehua 1 ; Tu, Xiongbing 1 ; Wang, Guangjun 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China

2.Minist Agr & Rural Affairs, Sci Observat & Expt Stn Pests Xilingol Rangeland, Xilinhot 026000, Peoples R China

3.Univ Swabi, Dept Agr, Khyber Pakhtunkhwa 23561, Pakistan

4.Chinese Acad Agr Sci, Inst Plant Protect, MARA CABI Joint Lab Biosafety, Beijing 100193, Peoples R China

5.Mongolian Univ Life Sci, Sch Agroecol, Ulaanbaatar 17024, Mongolia

6.Ningxia Acad Agr & Forestry Sci, Inst Plant Protect, Yinchuan 750002, Peoples R China

关键词： Antifungal immunity; Bio-pesticides; FKBP; Locusta migratoria; Metarhizium anisopliae

期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 0048-3575

年卷期： 2023 年 195 卷

页码：

收录情况： SCI

摘要： Locusta migratoria is one of the most destructive pests that threaten crop growth and food production security in China. Metarhizium anisopliae has been widely used to control locusts around the world. Previous laboratory studies have revealed that LmFKBP24 is significantly upregulated after M. anisopliae infection, suggesting that it may play a role in immune regulation, yet the mechanism remains largely unknown. To gain further insight, we conducted an RNA interference (RNAi) study to investigate the function of LmFKBP24 in the regulation of antifungal immunity and analyzed the expression patterns of immune-induced genes. Our research revealed that LmFKBP24 is activated and upregulated when locusts are infected by M. anisopliae, and it inhibits the expression of antimicrobial peptide (AMP) defensin in the downstream of Toll pathway by combining with LmEaster rather than LmCyPA, thus exerting an immunosuppressive effect. To further investigate this, we conducted yeast two hybrid (Y2H) and pull down assays to identify the proteins interacting with LmFKBP24. Our results provided compelling evidence for revealing the immune mechanism of L. migratoria and uncovered an innovative target for the development of new biological pesticides. Furthermore, our research indicates that LmFKBP24 interacts with LmEaster through its intact structure, providing a strong foundation for further exploration.

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