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Transcriptional factor OmpR positively regulates prodigiosin biosynthesis in Serratia marcescens FZSF02 by binding with the promoter of the prodigiosin cluster

文献类型： 外文期刊

作者： Jia, Xianbo 1 ; Zhao, Ke 2 ; Liu, Fangchen 2 ; Lin, Junjie 3 ; Lin, Chenqiang 1 ; Chen, Jichen 1 ;

作者机构： 1.Fujian Acad Agr Sci, Inst Soil & Fertilizer, Fujian Key Lab Plant Nutr & Fertilizer, Fuzhou, Peoples R China

2.Fujian Agr & Forestry Univ, Coll Resources & Environm, Fuzhou, Peoples R China

3.Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou, Peoples R China

关键词： Serratia marcescens; prodigiosin; OmpR; two-component system; regulatory mechanism

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：6.064； 五年影响因子：6.843 ）

ISSN：

年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： Prodigiosin is a promising secondary metabolite mainly produced by Serratia marcescens. The production of prodigiosin by S. marcescens is regulated by different kinds of regulatory systems, including the EnvZ/OmpR system. In this study, we demonstrated that the regulatory factor OmpR positively regulated prodigiosin production in S. marcescens FZSF02 by directly binding to the promoter region of the prodigiosin biosynthesis cluster with a lacZ reporter assay and electrophoretic mobility shift assay (EMSA). The binding sequence with the pig promoter was identified by a DNase I footprinting assay. We further demonstrate that OmpR regulates its own expression by directly binding to the promoter region of envZ/ompR. For the first time, the regulatory mechanism of prodigiosin production by the transcriptional factor OmpR was revealed.

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