文献类型： 外文期刊

作者： Lv, Feng-Hua ¹ ; Cao, Yin-Hong ² ; Liu, Guang-Jian ⁴ ; Luo, Ling-Yun ¹ ; Lu, Ran ¹ ; Liu, Ming-Jun ⁵ ; Li, Wen-Rong ⁵ ; Zhou, Ping ⁶ ; Wang, Xin-Hua ⁶ ; Shen, Min ⁶ ; Gao, Lei ⁶ ; Yang, Jing-Quan ⁶ ; Yang, Hua ⁶ ; Yang, Yong-Lin ⁶ ; Liu, Chang-Bin ⁶ ; Wan, Peng-Cheng ⁶ ; Zhang, Yun-Sheng ⁶ ; Pi, Wen-Hui ⁶ ; Ren, Yan-Ling ⁸ ; Shen, Zhi-Qiang ⁸ ; Wang, Feng ⁹ ; Wang, Yu-Tao ¹⁰ ; Li, Jin-Quan ¹¹ ; Salehian-Dehkordi, Hosein ² ; Hehua, Eer ¹² ; Liu, Yong-Gang ¹³ ; Chen, Jian-Fei ¹ ; Wang, Jian-Kui ¹ ; Deng, Xue-Mei ¹ ; Esmailizadeh, Ali ¹⁴ ; Dehghani-Qanatqestani, Mostafa ¹ ; Charati, Hadi ¹⁴ ; Nosrati, Maryam ¹⁵ ; Stepanek, Ondrej ¹⁶ ; Rushdi, Hossam E. ¹⁴ ; Olsaker, Ingrid ¹⁷ ; Curik, Ino ¹⁸ ; Gorkhali, Neena A. ¹⁹ ; Paiva, Samuel R. ²⁰ ; Caetano, Alexandre R. ²⁰ ; Ciani, Elena ²¹ ; Amills, Marcel ²² ; Weimann, Christina ²⁴ ; Erhardt, Georg ²⁴ ; Amane, Agraw ²⁵ ; Mwacharo, Joram M. ²⁷ ; Han, Jian-Lin ³⁰ ; Hanotte, Olivier ²⁶ ; Periasamy, Kathiravan ³³ ; Johansson, Anna M. ³⁴ ; Hallsson, Jon H. ³⁵ ; Kantanen, Juha ³⁶ ; Coltman, David W. ³⁷ ; Bruford, Michael W. ³⁸ ; Lenstra, Johannes A. ⁴⁰ ; Li, Meng-Hua ¹ ;

作者机构： 1.China Agr Univ, Coll Anim Sci & Technol, Beijing, Peoples R China

2.Chinese Acad Sci, Inst Zool, CAS Key Lab Anim Ecol & Conservat Biol, Beijing, Peoples R China

3.Univ Chinese Acad Sci UCAS, Coll Life Sci, Beijing, Peoples R China

4.Novogene Bioinformat Inst, Beijing, Peoples R China

5.Xinjiang Acad Anim Sci, Anim Biotechnol Res Ctr, Urumqi, Peoples R China

6.Xinjiang Acad Agr & Reclamat Sci, Inst Anim Husb & Vet Med, Shihezi, Peoples R China

7.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China

8.Shandong Binzhou Acad Anim Sci & Vet Med, Binzhou, Peoples R China

9.Nanjing Agr Univ, Inst Sheep & Goat Sci, Nanjing, Peoples R China

10.Kashi Univ, Coll Life & Geog Sci, Kashi, Peoples R China

11.Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot, Peoples R China

12.Ningxia Acad Agr & Forestry Sci, Grass Feeding Livestock Engn Technol Res Ctr, Yinchuan, Ningxia, Peoples R China

13.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming, Yunnan, Peoples R China

14.Shahid Bahonar Univ Kerman, Fac Agr, Dept Anim Sci, Kerman, Iran

15.Payame Noor Univ, Dept Agr, Tehran, Iran

16.State Vet Inst Jihlava, Dept Virol, Jihlava, Czech Republic; Cairo Univ, Fac Agr, Dept Anim Prod, Giza 12613, Egypt

17.Norwegian Univ Life Sci, Fac Vet Med, Dept Preclin Sci & Pathol, As, Norway

18.Univ Zagreb, Fac Agr, Dept Anim Sci, Zagreb, Croatia

19.Nepal Agr Res Council NARC, Natl Inst Anim Sci, Anim Breeding Div, Kathmandu, Nepal

20.PqEB, Embrapa Recursos Genet & Biotecnol, Parque Estacao Biol, Brasilia, DF, Brazil

21.Univ Bari Aldo 24 Moro, Dipartimento Biosci Biotecnol & Biofarmaceut, Bari, Italy

22.CSIC IRTA UAB UB, Ctr Res Agr Genom CRAG, Dept Anim Genet, Campus Univ Autonoma Barcelona, Bellaterra, Spain

23.Univ Autonoma Barcelona, Dept Anim Sci, Bellaterra, Spain

24.Justus Liebig Univ Giessen, Dept Anim Breeding & Genet, Giessen, Germany

25.Addis Ababa Univ, Dept Microbial Cellular & Mol Biol, Addis Ababa, Ethiopia

26.Int Livestock Res Inst, LiveGene Program, Addis Ababa, Ethiopia

27.Int Ctr Agr Res Dry Areas ICARDA, Small Ruminant Genom, Addis Ababa, Ethiopia

28.CTLGH, Roslin Inst Bldg,Easter Bush Campus, Edinburgh, Midlothian, Scotland

29.SRUC, Roslin Inst Bldg,Easter Bush Campus, Edinburgh, Midlothian, Scotland

30.Chinese Acad Agr Sci CAAS, Inst Anim Sci, CAAS ILRI Joint Lab Livestock & Forage Genet Reso, Beijing, Peoples R China

31.Int Livestock Res Inst ILRI, Livestock Genet Program, Nairobi, Kenya

32.Univ Nottingham, Sch Life Sci, Univ Pk, Nottingham, England

33.Int Atom Energy Agcy IAEA, Joint FAO IAEA Div, Anim Prod & Hlth Lab, Vienna, Austria

34.Swedish Univ Agr Sci, Fac Vet Med & Anim Sci, Dept Anim Breeding & Genet, Uppsala, Sweden

35.Agr Univ Iceland, Fac Nat Resources & Environm Sci, Borgarnes, Iceland

36.Nat Resources Inst Finland Luke, Prod Syst, Jokioinen, Finland

37.Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada

38.Cardiff Univ, Sch Biosci, Cathays Pk, Cardiff, Wales

39.Cardiff Univ, Sustainable Places Res Inst, Cardiff, Wales

40.Univ Utrecht, Fac Vet Med, Utrecht, Netherlands

关键词： whole-genome sequences; genetic diversity; adaptive introgression; genetic selection; agronomic traits; migration

期刊名称：MOLECULAR BIOLOGY AND EVOLUTION （ 影响因子：8.8； 五年影响因子：20.074 ）

ISSN： 0737-4038

年卷期： 2022 年 39 卷 2 期

页码：

收录情况： SCI

摘要： Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but their genome landscapes remain understudied. Here, we present a comprehensive genome resource for wild ovine species, landraces and improved breeds of domestic sheep, comprising high-coverage (similar to 16.10x) whole genomes of 810 samples from 7 wild species and 158 diverse domestic populations. We detected, in total, similar to 121.2 million single nucleotide polymorphisms, similar to 61 million of which are novel. Some display significant (P < 0.001) differences in frequency between wild and domestic species, or are private to continent-wide or individual sheep populations. Retained or introgressed wild gene variants in domestic populations have contributed to local adaptation, such as the variation in the HBB associated with plateau adaptation. We identified novel and previously reported targets of selection on morphological and agronomic traits such as stature, horn, tail configuration, and wool fineness. We explored the genetic basis of wool fineness and unveiled a novel mutation (chr25: T7,068,586C) in the 3 '-UTR of IRF2BP2 as plausible causal variant for fleece fiber diameter. We reconstructed prehistorical migrations from the Near Eastern domestication center to South-and-Southeast Asia and found two main waves of migrations across the Eurasian Steppe and the Iranian Plateau in the Early and Late Bronze Ages. Our findings refine our understanding of genome variation as shaped by continental migrations, introgression, adaptation, and selection of sheep.