Nagimycins A and B, Antibacterial Ansamycin-Related Macrolactams from Streptomyces sp. NA07423
文献类型： 外文期刊
作者： Guo, Zhi Kai 1 ; Wang, Yong Chao 3 ; Tan, Ying Zi 3 ; Abulaizi, Ailiman 1 ; Xiong, Zi Jun 1 ; Zhang, Shi Qing 1 ; Yang, Yang 4 ; Yang, La Ying 4 ; Shi, Jing 3 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Haikou 571101, Hainan, Peoples R China
3.Nanjing Univ, Inst Funct Biomol, Sch Life Sci,State Key Lab Pharmaceut Biotechnol, Chem & Biomed Innovat Ctr ChemBIC, Nanjing 210023, Peoples R China
4.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Haikou 571101, Hainan, Peoples R China
5.Natl Collect Microbial Resource Fertilizer Hainan, Haikou 571101, Hainan, Peoples R China
期刊名称：ORGANIC LETTERS （ 影响因子：5.2； 五年影响因子：4.9 ）
ISSN： 1523-7060
年卷期： 2023 年 25 卷 22 期
页码：
收录情况： SCI
摘要： Chemical investigation of Streptomyces sp. NA07423led to the discovery of two unreported macrolactams, nagimycins A(1) and B (2). Their structures were elucidatedby NMR, HRESIMS, X-ray crystallography, and comparison of experimentaland theoretical ECD spectra. The nagimycins have a unique butenolidemoiety rarely found in ansamycin antibiotics. Genome analysis revealedthe putative biosynthetic gene cluster for nagimycins, and a likelybiosynthetic pathway was proposed. Notably, compounds 1 and 2 exhibited potent antibacterial activity againsttwo pathogenic Xanthomonas bacteria.
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