Carbazomycins I and J, two novel carbazole alkaloids isolated from Saccharopolyspora phattalungensis
文献类型： 外文期刊
作者： Wang, Wen 1 ; Zhao, Er Juan 1 ; Peng, Ting 1 ; Yan, Zhang Yuan 1 ; Guo, Zhi Kai 2 ; Jiao, Rui Hua 1 ;
作者机构： 1.Nanjing Univ, Inst Funct Biomol, Chem & Biomed Innovat Ctr ChemBIC, Sch Life Sci,State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Peoples R China
3.Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Haikou 571101, Peoples R China
关键词： Microbial Natural Products; Carbazole alkaloids; Structural elucidation; Gene cluster; Biosynthesis pathway
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.7； 五年影响因子：1.8 ）
ISSN： 1874-3900
年卷期： 2024 年 60 卷
页码：
收录情况： SCI
摘要： Carbazomycins I (1) and J (2), two novel carbazole alkaloids were isolated from the fermentation broth of Saccharopolyspora phattalungensis DSM 45584. Their structures were elucidated by analysis of HRESIMS and NMR spectroscopic data. Compounds 1 and 2 were evaluated for their antimicrobial activities against seven pathogens by the agar diffusion method. Additionally, bioinformatics analysis revealed the biosynthetic gene cluster for carbazomycins (1) and J (2).
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