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LC-MS Guided Discovery and Biosynthetic Pathway of Coprisamides E-H, Cinnamic Acid-Containing Metabolites from the Marine Algae-Derived Streptomyces thermolineatus NAK03196

文献类型： 外文期刊

作者： Zhang, Guo Dong 1 ; Yang, Zhi Wei 1 ; Yin, Fang Zhou 1 ; Yan, Zhang Yuan 1 ; Xiong, Zi Jun 2 ; Ma, Shuai 2 ; Guo, Zhi Kai 1 ; Jiao, Rui Hua 1 ;

作者机构： 1.Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China

2.Chinese Acad Trop Agr Sci, Hainan Key Lab Trop Microbe Resources, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

3.Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.6； 五年影响因子：4.2 ）

ISSN： 0163-3864

年卷期： 2025 年 88 卷 3 期

页码：

收录情况： SCI

摘要： Four cinnamoyl-containing nonribosomal peptides (CCNPs), coprisamides E-H (1-4), were isolated from the marine algae-associated actinomycete strain Streptomyces thermolineatus NAK03196. Their structures were elucidated to be unreported coprisamides by comprehensive analyses of HRESIMS, 1D and 2D NMR spectroscopic data, Marfey's method, and MS/MS analysis. Coprisamides E (1) and F (2) bear a characteristic nonproteinogenic amino acid, 2,3-diaminopropanoic acid. The biosynthetic pathways for these isolates were proposed through a comparison of their biosynthetic gene clusters with reported homologous gene clusters. Coprisamide E (1) exhibited weak antibacterial activity against the Gram-positive strain Staphylococcus aureus.

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