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Maduraflavacins A-E, Unusual Phenyl Polyene Metabolites Produced by a Rare Marine-Derived Actinomadura sp.

文献类型： 外文期刊

作者： Zou, Yan 1 ; Shi, Jing 1 ; Sun, Jia Lin 1 ; Li, Ling Yu 1 ; Yan, Zhang Yuan 1 ; Guo, Zhi Kai 2 ; Jiao, Rui Hua 1 ;

作者机构： 1.Nanjing Univ, Inst Funct Biomol, Chem & Biomed Innovat Ctr ChemBIC, Sch Life Sci,State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Peoples R China

3.Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.6； 五年影响因子：4.2 ）

ISSN： 0163-3864

年卷期： 2024 年 87 卷 10 期

页码：

收录情况： SCI

摘要： Phenyl polyenes comprise a small family of bacterial natural products with broad and potent bioactivities, primarily found in actinobacteria. Here we report the discovery of five new phenyl polyene metabolites, maduraflavacins A-E (1-5), from a rare, marine-derived actinobacteria strain Actinomadura glauciflava NA03286. The structures of these natural products were determined by NMR spectroscopy, HRESIMS, LC-MS/MS, and chemical derivatization. All of these new maduraflavacins feature methyl substitutions at the polyene side chain, and maduraflavacins A-C (1-3) possessed a 1-N-beta-d-glucosamine-(3 -> 1)-O-beta-d-glucopyranosyl-(3 -> 1)-O-beta-d-glucopyranosyl-(6 -> 1)-O-beta-d-glucopyranoside tetrasaccharide moiety via an amido linkage with a phenyl polyene skeleton. Compounds 1 and 2 showed weak antibacterial activities against the Gram-positive bacteria Staphylococcus aureus Sau 16339 and Micrococcus luteus, respectively.

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