您好，欢迎访问中国热带农业科学院 机构知识库！
中国热带农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Pseudovenmycin, a novel lasso peptide from Streptomyces pseudovenezuelae NA07851

文献类型： 外文期刊

作者： Yan, Zhang Yuan 1 ; Qu, Kai Jie 1 ; Li, Ling Yu 1 ; Wang, Zi Ru 1 ; He, Wen 1 ; Guo, Zhi Kai 2 ; Tan, Ren Xiang 1 ;

作者机构： 1.Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Peoples R China

3.Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China

关键词： Pseudovenmycin; Lasso peptide; Heterologous expression; NMR; Antimicrobial activity

期刊名称：TETRAHEDRON LETTERS （ 影响因子：1.5； 五年影响因子：1.5 ）

ISSN： 0040-4039

年卷期： 2025 年 170 卷

页码：

收录情况： SCI

摘要： Pseudovenmycin (1), a novel type III lasso peptide with a disulfide bond formed by two cysteines, was discovered from Streptomyces pseudovenezuelae NA07851 isolated from a marine sediment collected at the seaside of Fuzhou, Fujian province, China. The biosynthetic gene cluster (BGC) (pvm) responsible for the biosynthesis of pseudovenmycin was successfully identified through heterologous expression in Streptomyces albus J1074 strain and thus its efficient production was achieved. The planar structure of pseudovenmycin was assigned by comprehensive analysis of NMR spectroscopy, LC-MS/MS fragmentation and gene sequence. The absolute configurations of the amino acid residues in this compound were confirmed by Marfey's method. Pseudovenmycin displayed weak inhibitory activity against three tested phytopathogenic fungi.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国热带农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台