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Kinetics and Distribution of Zearalenone-14-Glucoside and Its Metabolite Zearalenone in Rat, Determined by a Reliable HPLC-MS/MS Method

文献类型： 外文期刊

作者： Cai, Yaling 1 ; Zhang, Zhiqi 2 ; Dong, Fang 2 ; Ma, Zefeng 2 ; Fan, Kai 2 ; Han, Zheng 2 ; Li, Zhizhong 1 ; Zhao, Zhihui 2 ;

作者机构： 1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China

2.Shanghai Acad Agr Sci, Inst Agrofood Stand & Testing Technol, Shanghai 201403, Peoples R China

关键词： zearalenone-14-glucoside; zearalenone; HPLC-MS; MS; rat plasma; urine; tissues

期刊名称：APPLIED SCIENCES-BASEL （ 影响因子：2.7； 五年影响因子：2.9 ）

ISSN：

年卷期： 2023 年 13 卷 8 期

页码：

收录情况： SCI

摘要： A reliable high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was established for the simultaneous detection of zearalenone-14-glucoside (ZEN-14G) and its metabolite, zearalenone (ZEN), in the plasma, urine, and various tissues of rats. The performance of the developed method was validated by determining the selectivity, linearity (R-2 > 0.99), sensitivity (lower limit of quantification, 0.1-1 mu g/L), recovery (80.7 +/- 3.0-112.3 +/- 3.1%), precision (0.6-16.5%), and stability (81.7 +/- 1.7-104.1 +/- 3.9%). Through use of the methodological advances, the subsequent kinetics and distribution after administration of ZEN-14G by gavage were thoroughly investigated. ZEN-14G and ZEN exhibited similar trends in the plasma, and reached their peak concentrations at 10 min and then rapidly decreased. ZEN-14G could be quantified in the stomach, small intestine, and large intestine 24 h after administration, while ZEN was detectable in all tested tissues. Interestingly, ZEN-14G (7.6 +/- 3.0 mu g/L) and ZEN (977.5 +/- 98.0 mu g/L) were also detected in the urine 24 h after administration, indicating that ZEN-14G was prone to be slowly and continuously hydrolyzed into ZEN to be absorbed into the plasma and distributed to various tissues, thus leading to a cumulative exposure. Continuous attention should be paid to the co-exposure of ZEN and ZEN-14G, which might pose additional health risks to humans and animals.

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