Efficient heterologous biosynthesis of verazine, a metabolic precursor of the anti-cancer drug cyclopamine, in Nicotiana benthamiana
文献类型： 外文期刊
作者： Kou, Chengxi 1 ; Liu, Jingling 1 ; Yin, Xue 2 ; He, Di 1 ; Liu, Jia 2 ; Hua, Xin 2 ; Ma, Rui 4 ; Sun, Wei 5 ; Xue, Zheyong 2 ; Ma, Pengda 1 ;
作者机构： 1.Northwest A&F Univ, Coll Life Sci, Yangling 712100, Peoples R China
2.Northeast Forestry Univ, Key Lab Saline Alkali Vegetat Ecol Restorat, Minist Educ, Harbin 150040, Peoples R China
3.Northeast Forestry Univ, Heilongjiang Key Lab Plant Bioact Subst Biosynth &, Harbin 150040, Peoples R China
4.Jilin Acad Agr Sci, Jilin Prov Key Lab Agr Biotechnol, Changchun 130033, Peoples R China
5.China Acad Chinese Med Sci, Inst Chinese Mat Med, Key Lab Beijing Identificat & Safety Evaluat Chine, Beijing 100700, Peoples R China
期刊名称：PLANT COMMUNICATIONS （ 影响因子：11.6； 五年影响因子：11.8 ）
ISSN： 2590-3462
年卷期： 2024 年 5 卷 6 期
页码：
收录情况： SCI
摘要： Among the large number of Veratrum steroid alkaloids (Zhang inhibitory mechanisms against cancer, including inhibition of the hedgehog signaling pathway, improvement of tumor tissue microenvironment, inhibition of cell respiration, promotion of cell apoptosis, and reversal of tumor drug resistance (Liu metabolic precursor of cyclopamine, has been discovered in content of Veratrum steroid alkaloids in plants is very low (Supplemental Figure 2), so reliance on direct extraction from plants for commercial production is not feasible. A more effective strategy is to synthesize rare plant secondary
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