Uptake, Tissue Distribution, and Elimination of 8:2 Polyfluoroalkyl Phosphate Diesters in Mytilus galloprovincialis
文献类型： 外文期刊
作者： Cui, Wenjie 1 ; Tan, Zhijun 1 ; Chen, Jiaqi 1 ; Wu, Haiyan 1 ; Geng, Qianqian 1 ; Guo, Mengmeng 1 ; Zhai, Yuxiu 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao, Peoples R China
2.Ocean Univ China, Coll Food Sci & Engn, Qingdao, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol, Qingdao, Peoples R China
关键词： 8; 2 Polyfluoroalkyl phosphate diesters; Uptake; Tissue distribution; Elimination; Mytilus galloprovincialis
期刊名称：ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY （ 影响因子：3.742； 五年影响因子：3.866 ）
ISSN： 0730-7268
年卷期： 2021 年 40 卷 7 期
页码：
收录情况： SCI
摘要： Although the distribution of 8:2 polyfluoroalkyl phosphate diester (8:2 diPAP) in aquatic environments has been reported, details on its uptake, tissue specificity, and elimination in bivalve mollusks remain to be clarified. The present study is the first report on the accumulation and elimination of 8:2 diPAP in mussels (Mytilus galloprovincialis). The tissue-specific accumulation and depuration of 8:2 diPAP and its metabolites were investigated via semistatic seawater exposure (8:2 diPAP at a nominal concentration of 10 mu g/L), through water-borne exposure with static daily renewal over a 72-h exposure period and a 360-h depuration period. The digestive gland was found to be the target organ where accumulation and biotransformation primarily occur. The bioaccumulation factor values (mL/g dry wt) in different organs were in the following order: digestive gland (1249) > adductor muscle (315) > gills (289) > gonad (82.9) > mantle (33.0). Moreover, the distribution of 8:2 diPAP among tissues may be related to the total protein content. The 8:2 diPAP tended to be excreted in feces. The compounds 8:2 fluorotelomer carboxylic acid, 8:2 fluorotelomer unsaturated carboxylic acid, 7:3 fluorotelomer carboxylic acid, perfluorooctanoic acid, and perfluoroheptanoic acid were detected and quantified as phase I metabolites, and the concentration of all phase I metabolites relative to the 8:2 diPAP concentration (72 h) was 0.304 mol%. A phase II metabolite, 8:2 fluorotelomer alcohol conjugated with sulfate, was detected but not quantitated in the digestive gland. A biotransformation pathway of 8:2 diPAP in M. galloprovincialis was proposed on the basis of the results obtained in the present study and previous studies. These findings improve our understanding of the accumulation of perfluorocarboxylic acids in bivalve mollusks. Environ Toxicol Chem 2021;00:1-13. (c) 2021 SETAC
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