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Preparation, characterization and immunoregulatory activity of derivatives of polysaccharide from Atractylodes lancea (Thunb.) DC

文献类型： 外文期刊

作者： Liu, Chun-yao 1 ; Hu, De-jun 2 ; Zhu, Hua 3 ; Zhang, Ying-yue 3 ; Qin, Jing 1 ; Wang, Fang 4 ; Zhang, Zhi-Dong 5 ; Lv, Guang-ping 6 ;

作者机构： 1.Nanjing Tech Univ, Sch Pharmaceut Sci, Nanjing 211816, Peoples R China

2.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China

3.Nanjing Normal Univ, Sch Life Sci, Nanjing 210023, Peoples R China

4.Jiangxi Univ Chinese Med, Key Lab Modern Preparat Tradit Chinese Med, Minist Educ, Nanchang, Peoples R China

5.Xinjiang Acad Agr Sci, Inst Appl Microbiol, Xinjiang Lab Special Environm Microbiol, Urumqi 830091, Peoples R China

6.Nanjing Normal Univ, Sch Food & Pharmaceut Engn, Nanjing 210023, Peoples R China

7.Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, 1 Wenyuan Rd, Nanjing 210023, Peoples R China

关键词： Atractylodes lancea (Thunb; ) DC; polysaccharides; Derivatives; Chemical modification; Immunoregulatory activities

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.025； 五年影响因子：7.626 ）

ISSN： 0141-8130

年卷期： 2022 年 216 卷

页码：

收录情况： SCI

摘要： A polysaccharide (ALP-1) extracted from Atractylodes lancea (Thunb.) DC. was carboxymethylated (C-ALP-1), phosphorylated (P-ALP-1) and acetylated (A-ALP-1) to improve its physicochemical properties and bioactivities. The solubility of all derivatives was increased, and the solubility of A-ALP-1 increased to 137.5 mg/mL, which was much higher than the solubility of ALP-1 (15.0 mg/mL). The results of HPSEC-MALLS-RID showed that the molecular weight of polysaccharides was slightly increased after the modification, and the root mean square radius of rotation (Rz) and morphology of polysaccharides in solution were also changed. The scanning electron microscopy (SEM) and X-ray diffraction (XRD) results confirmed that the surface morphology of ALP-1 changed dramatically and the crystallinity decreased after structural modification. From thermal analysis results, the T50 of ALP-1, C-ALP-1, P-ALP-1 and A-ALP-1 were 281.34, 292.14, 333.75 and 298.70 degrees C, which showed that derivatives had stronger thermal stability than ALP-1. The immunomodulatory activity studies displayed that PALP-1 showed the best ability to stimulate RAW264.7 macrophages to release NO, and A-ALP-1 showed the best capacity to stimulate TNF-alpha and IL-6 releasing. These results indicated that chemical modification could enhance the solubility, the thermal stability and immunomodulatory activity of polysaccharides, which is beneficial for the development and utilization of natural polysaccharides.

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