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Getah Virus: A New Contaminant in Veterinary Vaccines

文献类型： 外文期刊

作者： Chu, Pin-Pin 1 ; Chen, Sheng-Nan 2 ; Zhou, Xia 1 ; Wei, Zu-Zhang 2 ; Zhai, Shao-Lun 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Dept Swine Dis, Inst Anim Hlth,Minist Agr & Rural Affairs,Guangdon, Guangzhou 510640, Peoples R China

2.Guangxi Univ, Coll Anim Sci & Technol, Lab Anim Infect Dis & Mol Immunol, Nanning 530005, Peoples R China

3.Guangzhou Sino Sci Gene Testing Serv Co Ltd, Guangzhou 510700, Peoples R China

关键词： porcine reproductive and respiratory syndrome virus; Getah virus; live vaccine contaminant; vaccination infection; exogenous pathogens

期刊名称：VETERINARY SCIENCES （ 影响因子：2.3； 五年影响因子：2.4 ）

ISSN：

年卷期： 2025 年 12 卷 2 期

页码：

收录情况： SCI

摘要： Vaccines are essential for the prevention and control of infectious diseases in livestock farming. Among these, live veterinary vaccines play an important role. The production of live vaccines requires high-level biosafety, toxicity and potential contaminants should be closely monitored. Unfortunately, other viral contaminants in commercial live-attenuated vaccines against a multitude of viruses have been discovered, which are difficult to detect and can cause huge losses. Similar situations have occurred in commercial live-attenuated vaccines against porcine reproductive and respiratory syndrome virus (PRRSV), which arouses our considerable interest. Mycoplasma, reticuloendotheliosis virus (REV), avian leukosis virus (ALV), chicken infectious anemia virus (CIAV), bovine polyomavirus (BPV), bovine viral diarrhea virus (BVDV), and porcine circovirus (PCV) are considered common contaminants in live veterinary vaccines against Newcastle disease virus (NDV), fowlpox virus (FPV), infectious bursal disease virus (IBDV), classical swine fever virus (CSFV), pseudorabies virus (PRV), and porcine reproductive and respiratory syndrome virus (PRRSV). In the past five years, Getah virus (GETV), an arbovirus affecting many farming mammals, was reported as a new contaminant in live PRRSV vaccines in two previous studies, which arouses our considerable interest. Therefore, in this paper, we aim to analyze and discuss the source, biological hazard, and genomic characteristics of these contaminating GETV strains further.

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