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The Innate Immune Response to Infection by Polyascus gregaria in the Male Chinese Mitten Crab (Eriocheir sinensis), Revealed by Proteomic Analysis

文献类型： 外文期刊

作者： Yang, Yanping 1 ; Ma, Fengjiao 3 ; Dong, Juanjuan 2 ; Li, Lianxing 2 ; Ren, Ping 2 ; Zhang, Yuning 3 ; Wu, Yatao 1 ; Wang, Yinping 2 ; Liu, Kai 2 ; Zhang, Fang 1 ;

作者机构： 1.Anhui Normal Univ, Coll Life Sci, Wuhu 241000, Peoples R China

2.Freshwater Fisheries Res Ctr, CAFS, Minist Agr & Rural Affairs, Sci Observing & Expt Stn Fishery Resources & Envi, Wuxi 214081, Jiangsu, Peoples R China

3.Nanjing Agr Univ, Wuxi Fishery Coll, Wuxi 214081, Jiangsu, Peoples R China

关键词： Eriocheir sinensis; Polyascus gregaria; TMT; innate immune; Yangtze Estuary

期刊名称：FISHES （ 影响因子：3.17； 五年影响因子：3.098 ）

ISSN：

年卷期： 2021 年 6 卷 4 期

页码：

收录情况： SCI

摘要： The Chinese mitten crab (Eriocheir sinensis) is a representative catadromous invertebrate of the Yangtze River and a commercial species widely cultivated in China. Both cultivated and wild crabs suffer from a variety of parasites and pathogens, which can result in catastrophic economic losses in aquaculture revenue. Polyascus gregaria, a parasitic barnacle with a highly derived morphology, is specialized in invading these crabs. This study examines the immunological mechanism in E. sinensis infected with P. gregaria. Tandem mass tags (TMT), a specialized method of mass-spectrometry, was used to analyze the infection by P. gregaria resistance at the protein level. In the hepatopancreas of infected crabs, 598 proteins differentially expressed relating to physiological change, of which, 352 were upregulated and 246 were downregulated. Based on this differential protein expression, 104 GO terms and 13 KEGG pathways were significantly enriched. Differentially expressed proteins, such as ATG, cathepsin, serpin, iron-related protein, Rab family, integrin, and lectin, are associated with the lysosome GO term and the autophagy-animal KEGG pathways, both of which likely relate to the immune response to the parasitic P. gregaria infection. These results show the benefit of taking a detailed, protein-level approach to understanding the innate immune response of aquatic invertebrates to macroparasite infection.

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