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Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells

文献类型： 外文期刊

作者： Zou, Xian-Guo 1 ; Xu, Meng-Ting 1 ; Dong, Xiao-Li 3 ; Ying, You-Min 5 ; Guan, Rong-Fa 1 ; Wu, Wei-Cheng 6 ; Yang, Kai 1 ; Sun, Pei-Long 1 ;

作者机构： 1.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Peoples R China

2.Zhejiang Univ Technol, Key Lab Food Macromol Resources Proc Technol Res, China Natl Light Ind, Beijing, Peoples R China

3.Hong Kong Polytech Univ, Food Safety & Technol Res Ctr, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

4.Hong Kong Polytech Univ, Shenzhen Inst, Key Lab Food Biol Safety Control, Shenzhen, Peoples R China

5.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

6.Zhejiang Acad Agr Sci, Food Sci Inst, Hangzhou, Peoples R China

关键词： 6-hydroxydopamine; Antrodia camphorata; dopaminergic neuron; neuroprotective activities; solid-state-cultured mycelium

期刊名称：JOURNAL OF FOOD BIOCHEMISTRY （ 影响因子：3.654； 五年影响因子：3.271 ）

ISSN： 0145-8884

年卷期： 2022 年 46 卷 8 期

页码：

收录情况： SCI

摘要： Antrodia camphorata (A. camphorata) is an edible fungus containing various bioactive compounds generally used for health benefits. This study aimed to explore the potential neuroprotective activities of solid-state-cultured mycelium of A. camphorata (SCMAC) against Parkinson's disease (PD), as well as the underlying mechanism using an in vitro 6-hydroxydopamine (6-OHDA)-induced PC12 cell model. The results showed that SCMAC extracts alleviated cell toxicity induced by 6-OHDA and the loss of dopaminergic neurons, which was confirmed by the increase of cell viabilities, inhibition of cell apoptosis, the upregulation of tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels and the downregulation of alpha-Synuclein level. After purification, 11 compounds were identified by the NMR technique, including a quinone, four phenolic acid derivatives, three ubiquinone derivatives, two alkaloids, and a triterpenoid. The present study suggests that SCMAC could be an attractive candidate for the prevention or treatment of PD. Practical applications Parkinson's disease seriously affects the lifetime and quality of the elder population for a long history. Long-term consumption of L-DOPA will result in side effects, such as developing abnormal involuntary movements called dyskinesia. This study showed that natural SCMAC extracts could be a potential therapeutic agent for the treatment of neurodegenerative disorder.

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