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Targeting microbiota-host interactions with resveratrol on cancer: Effects and potential mechanisms of action

文献类型： 外文期刊

作者： Wang, Pan 1 ; Shang, Runze 2 ; Ma, Yue 1 ; Wang, Dan 1 ; Zhao, Wenting 1 ; Chen, Fang 3 ; Hu, Xiaosong 3 ; Zhao, Xiaoyan 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Beijing Key Lab Agr Prod Fruits & Vegetables Pres, Key Lab Vegetable Postharvest Proc, Inst Agri food Proc & Nutr,Minist Agr & Rural Aff, Beijing, Peoples R China

2.Huaqiao Univ 910 Hosp, Dept Gen Surg, Affiliated Haixia Hosp, Quanzhou, Fujian, Peoples R China

3.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing, Peoples R China

关键词： Resveratrol; anticancer activity; metabolism characterization; gut microbiota; metabolites

期刊名称：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION （ 影响因子：11.208； 五年影响因子：12.104 ）

ISSN： 1040-8398

年卷期：

页码：

收录情况： SCI

摘要： Resveratrol (RSV) is a natural polyphenolic compound detected in grapes, berries, and red wine. The anticancer activities of RSV have been observed in vivo and in vitro studies. However, the pharmacology mechanism of RSV is confusing due to its low bioavailability. According to studies of the metabolic characteristics of RSV, the gut intestine is a crucial site of its health benefits. Dietary RSV exhibits a profound effect on the gut microbiota structure and metabolic function. In addition, emerging evidence demonstrates a protective effect of RSV metabolites against carcinogenesis. Therefore, to better understand the anticancer mechanisms of dietary RSV, it is vital to evaluate the role of RSV-microbiota-host interactions in cancer therapy. In this review, we summarized significant findings on the anticancer activities of RSV based on epidemiological, experimental and clinical studies involved in investigating the metabolic characteristics and the traditional anticancer mechanisms of RSV. Special attention is given to the putative mechanisms involving microbiota-host interactions, such as the modulation of gut microecology and the anticancer effects of RSV metabolites. The changes in microbiota-host interactions after RSV supplementation play vital roles in cancer prevention and thus offering a new perspective on nutritional interventions to treat cancer.

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