文献类型： 外文期刊

作者： Jayakodi, Murukarthick ¹ ; Lu, Qiongxian ² ; Pidon, Helene ¹ ; Rabanus-Wallace, M. Timothy ¹ ; Bayer, Micha ⁴ ; Lux, Thomas ⁵ ; Guo, Yu ¹ ; Jaegle, Benjamin ⁶ ; Badea, Ana ⁷ ; Bekele, Wubishet ⁸ ; Brar, Gurcharn S. ⁹ ; Braune, Katarzyna ² ; Bunk, Boyke ¹⁰ ; Chalmers, Kenneth J. ¹¹ ; Chapman, Brett ¹² ; Jorgensen, Morten Egevang ² ; Feng, Jia-Wu ¹ ; Feser, Manuel ¹ ; Fiebig, Anne ¹ ; Gundlach, Heidrun ⁵ ; Guo, Wenbin ⁴ ; Haberer, Georg ⁵ ; Hansson, Mats ¹³ ; Himmelbach, Axel ¹ ; Hoffie, Iris ¹ ; Hoffie, Robert E. ¹ ; Hu, Haifei ¹² ; Isobe, Sachiko ¹⁵ ; Koenig, Patrick ¹ ; Kale, Sandip M. ² ; Kamal, Nadia ⁵ ; Keeble-Gagnere, Gabriel ¹⁶ ; Keller, Beat ⁶ ; Knauft, Manuela ¹ ; Koppolu, Ravi ¹ ; Krattinger, Simon G. ¹⁷ ; Kumlehn, Jochen ¹ ; Langridge, Peter ¹¹ ; Li, Chengdao ¹² ; Marone, Marina P. ¹ ; Maurer, Andreas ²⁰ ; Mayer, Klaus F. X. ⁵ ; Melzer, Michael ¹ ; Muehlbauer, Gary J. ²² ; Murozuka, Emiko ² ; Padmarasu, Sudharsan ¹ ; Perovic, Dragan ²³ ; Pillen, Klaus ²⁰ ; Pin, Pierre A. ²⁴ ; Pozniak, Curtis J. ²⁵ ; Ramsay, Luke ⁴ ; Pedas, Pai Rosager ² ; Rutten, Twan ¹ ; Sakuma, Shun ²⁷ ; Sato, Kazuhiro ¹⁵ ; Schueler, Danuta ¹ ; Schmutzer, Thomas ²⁰ ; Scholz, Uwe ¹ ; Schreiber, Miriam ⁴ ; Shirasawa, Kenta ¹⁵ ; Simpson, Craig ⁴ ; Skadhauge, Birgitte ² ; Spannagl, Manuel ⁵ ; Steffenson, Brian J. ²⁹ ; Thomsen, Hanne C. ² ; Tibbits, Josquin F. ¹⁶ ; Nielsen, Martin Toft Simmelsgaard ² ; Trautewig, Corinna ¹ ; Vequaud, Dominique ²⁴ ; Voss, Cynthia ² ; Wang, Penghao ¹² ; Waugh, Robbie ⁴ ; Westcott, Sharon ¹² ; Rasmussen, Magnus Wohlfahrt ² ; Zhang, Runxuan ⁴ ; Zhang, Xiao-Qi ¹² ; Wicker, Thomas ⁶ ; Dockter, Christoph ² ; Mascher, Martin ¹ ; Stein, Nils ¹ ;

作者机构： 1.Leibniz Inst Plant Genet & Crop Plant Res IPK, Gatersleben, Seeland, Germany

2.Carlsberg Res Lab, Copenhagen, Denmark

3.Univ Montpellier, Inst Agro, IPSiM, CNRS,INRAE, Montpellier, France

4.James Hutton Inst, Dundee, Scotland

5.Helmholtz Ctr Munich, German Res Ctr Environm Hlth, PGSB Plant Genome & Syst Biol, Neuherberg, Germany

6.Univ Zurich, Dept Plant & Microbial Biol, Zurich, Switzerland

7.Agr & Agrifood Canada, Brandon Res & Dev Ctr, Brandon, MB, Canada

8.Agr & Agrifood Canada, Ottawa Res & Dev Ctr, Ottawa, ON, Canada

9.Univ British Columbia, Fac Land & Food Syst, Vancouver, BC, Canada

10.DSMZ German Collect Microorganisms & Cell Cultures, Braunschweig, Germany

11.Univ Adelaide, Sch Agr Food & Wine, Urrbrae, SA, Australia

12.Murdoch Univ, Food Futures Inst, Sch Agr, Western Crop Genet Alliance, Murdoch, WA, Australia

13.Lund Univ, Dept Biol, Lund, Sweden

14.Guangdong Acad Agr Sci, Rice Res Inst, Guangzhou, Peoples R China

15.Kazusa DNA Res Inst, Kisarazu, Japan

16.La Trobe Univ, Dept Jobs Precincts & Reg, Dept Jobs Precincts & Reg, Agribio, Bundoora, Vic, Australia

17.King Abdullah Univ Sci & Technol KAUST, Plant Sci Program, Biol & Environm Sci & Engn Div, Thuwal, Saudi Arabia

18.Govt Western Australia, Dept Primary Ind & Reg Dev, Perth, WA, Australia

19.Yangtze Univ, Coll Agr, Jingzhou, Peoples R China

20.Martin Luther Univ Halle Wittenberg, Inst Agr & Nutr Sci, Halle, Germany

21.Tech Univ Munich, Sch Life Sci Weihenstephan, Freising Weihenstephan, Germany

22.Univ Minnesota, Dept Agron & Plant Genet, St Paul, MN USA

23.Julius Kuehn Inst JKI, Inst Resistance Res & Stress Tolerance, Fed Res Ctr Cultivated Plants, Quedlinburg, Germany

24.SECOBRA Rech, Maule, France

25.Univ Saskatchewan, Dept Plant Sci, Saskatoon, SK, Canada

26.Univ Saskatchewan, Crop Dev Ctr, Saskatoon, SK, Canada

27.Tottori Univ, Fac Agr, Tottori, Japan

28.Okayama Univ, Inst Plant Sci & Resources, Kurashiki, Japan

29.Univ Minnesota, Dept Plant Pathol, St Paul, MN USA

30.Univ Dundee, Sch Life Sci, Dundee, Angus, Scotland

31.German Ctr Integrat Biodivers Res iDiv, Leipzig, Germany

32.Univ Alberta, Fac Agr Life & Environm Sci ALES, Edmonton, AB, Canada

33.Aarhus Univ, Dept Agroecol, Slagelse, Denmark

期刊名称：NATURE （ 影响因子：48.5； 五年影响因子：55.0 ）

ISSN： 0028-0836

年卷期： 2024 年 636 卷 8043 期

页码：

收录情况： SCI

摘要： Pangenomes are collections of annotated genome sequences of multiple individuals of a species1. The structural variants uncovered by these datasets are a major asset to genetic analysis in crop plants2. Here we report a pangenome of barley comprising long-read sequence assemblies of 76 wild and domesticated genomes and short-read sequence data of 1,315 genotypes. An expanded catalogue of sequence variation in the crop includes structurally complex loci that are rich in gene copy number variation. To demonstrate the utility of the pangenome, we focus on four loci involved in disease resistance, plant architecture, nutrient release and trichome development. Novel allelic variation at a powdery mildew resistance locus and population-specific copy number gains in a regulator of vegetative branching were found. Expansion of a family of starch-cleaving enzymes in elite malting barleys was linked to shifts in enzymatic activity in micro-malting trials. Deletion of an enhancer motif is likely to change the developmental trajectory of the hairy appendages on barley grains. Our findings indicate that allelic diversity at structurally complex loci may have helped crop plants to adapt to new selective regimes in agricultural ecosystems.