Capillary Electrophoresis Coupling with Electrochemiluminescence for Bisoprolol, Emolol, Propranolol Enantioseparation and Detection
文献类型： 外文期刊
作者： Hu, Yuefang 1 ; Chen, Yuxin 2 ; Lin, Liyun 3 ; Liu, Guohua 1 ; Wang, Zhengguo 1 ; Liang, Dongmei 1 ;
作者机构： 1.Hezhou Univ, Sch Mat & Chem Engn, Hezhou 542899, Peoples R China
2.Guangxi Univ Chinese Med, Fac Chinese Med Sci, Nanning 530000, Peoples R China
3.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Guangdong, Peoples R China
关键词： Enantioseparation; I3-blocker drugs; capillary electrophoresis; electrochemiluminescence
期刊名称：INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE （ 影响因子：1.765； 五年影响因子：1.685 ）
ISSN： 1452-3981
年卷期： 2021 年 16 卷 10 期
页码：
收录情况： SCI
摘要： A simple, convenient and flexibility capillary electrophoresis coupling with electrochemiluminescence (CE-ECL) detection method was carried out for simultaneous enantioseparation of three I3-blocker drugs (bisoprolol, esmolol, propranolol). In CE-ECL system, the buffers of the capillary outside and inside was not the same including the buffer composition, pH value, and concentrations. In order to simultaneously improve the detection sensitivity and enantiomer separation, the conditions of capillary inlet and outlet buffer were optimized in detail. Under the optimized conditions, the separation efficiency for enantiomers of three I3-blocker drugs were improved and baseline resolution was achieved. The limit of detection (LOD) were in the range of 0.01-0.08 ng/mL for bisoprolol, esmolol, propranolol enanotiomers. The RSDs of peak areas peak, heights, and migration time were in the range of 2.1-2.5 %, 2.0-2.3 %, and 1.9-2.2 % for enanotiomers, respectively. The separation-detection techniques was applied to analysis enantiomers of bisoprolol, esmolol, propranolol in urine sample successfully, the recoveries of the six enantiomers were in the range of 94.0 %-100.7 % with RSDs less than 3.1 %.
- 相关文献
作者其他论文 更多>>
-
A dual-signal sensing strategy based on ratiometric fluorescence and colorimetry for determination of Cu2+ and glyphosate
作者：Yang, Yixia;Li, Li;Wang, Xianfeng;Li, Jiawei;Liu, Huan;Liu, Xiaofang;Huo, Danqun;Hou, Changjun;Lin, Liyun;Liu, Huan;Hou, Changjun
关键词：Ratiometric fluorescence; Colorimetric detection; Silicon nanoparticles; Organophosphorus pesticides; o-Phenylenediamine oxidation
-
A turn-on fluorescence sensor based on Cu2+ modulated DNA-templated silver nanoclusters for glyphosate detection and mechanism investigation
作者：Yang, Yixia;Ghalandari, Behafarid;Sang, Xiao;Su, Wenqiong;Ding, Xianting;Lin, Liyun;Divsalar, Adeleh
关键词：Fluorescence sensor; DNA-AgNCs; Organophosphorus pesticide; Mechanism investigation; Stoichiometric methods
-
Determination of fungaltoxin residues in bergamot pear by UPLC-MS/MS
作者：Lin, Ling;Ye, Jianzhi;Yang, Chunliang;Liu, Yuanjing;Guo, Hongbin;Zeng, Shaodong;Ma, Huifang;Lin, Liyun;Lin, Ling;Ye, Jianzhi;Yang, Chunliang;Liu, Yuanjing;Guo, Hongbin;Zeng, Shaodong;Ma, Huifang;Lin, Liyun
关键词：
-
Biomimetic Synthesis of Ultrafine Mixed-Valence Metal-Organic Framework Nanowires and Their Application in Electrochemiluminescence Sensing
作者：Ma, Xionghui;Pang, Chaohai;Li, Shuhuai;Wang, Mingyue;Luo, Jinhui;Xu, Zhi;Xiong, Yuhao;Su, Linjing;Lin, Liyun;Li, Jianping
关键词：metal-organic framework; nanowires; biomimetic synthesis; electrochemiluminescence sensor; molecular imprinting
-
A colorimetric sensing platform based on self-assembled 3D porous CeGONR nanozymes for label-free visual detection of organophosphate pesticides
作者：Lin, Liyun;Ma, Huifang;Yang, Chunliang;Chen, Wuhai;Zeng, Shaodong;Hu, Yuefang
关键词：
-
Chitosan-modified halloysite nanotubes as a controlled-release nanocarrier for nitrogen delivery
作者：Wang, Chao;He, Zuyu;Liu, Yunhao;Zhou, Chuang;Jiao, Jing;Li, Puwang;Sun, Dequan;Yang, Ziming;Wang, Chao;Lin, Liyun
关键词：Halloysite nanotubes; Chitosan; Surface modification; Fertilizer; Controlled release
-
P,N Codoped carbon dots as an efficient "off-on" fluorescent probe for lipoic acid detection and its cellular dual-color imaging
作者：Hu, Yuefang;Li, Jinfang;Hu, Yuefang;Lin, Liyun;Ye, Jianzhi
关键词：Codoped carbon dots; LA detection; Fluorescent probe; Cell imaging
