文献类型： 外文期刊
作者： Tan, Si 1 ; Ke, Zunli 3 ; Zhou, Chongbing 1 ; Luo, Yuping 1 ; Ding, Xiaobo 4 ; Luo, Gangjun 1 ; Li, Wenfeng 1 ; Shi, Shengyou 1 ;
作者机构： 1.Yangtze Normal Univ, Sch Adv Agr & Bioengn, Chongqing 408100, Peoples R China
2.Chinese Acad Trop Agr Sci, South Subtrop Crops Res Inst, Zhanjiang 524091, Peoples R China
3.Guizhou Univ Tradit Chinese Med, Basic Med Sch, Guiyang 550025, Peoples R China
4.Luzhou Acad Agr Sci, Luzhou, Peoples R China
关键词： longan; polyphenols; lipid metabolism; PPAR alpha; LXR alpha
期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）
ISSN：
年卷期： 2023 年 28 卷 5 期
页码：
收录情况： SCI
摘要： Longan, a popular fruit in Asia, has been used in traditional Chinese medicine to treat several diseases for centuries. Recent studies have indicated that longan byproducts are rich in polyphenols. The aim of this study was to analyze the phenolic composition of longan byproduct polyphenol extracts (LPPE), evaluate their antioxidant activity in vitro, and investigate their regulating effect on lipid metabolism in vivo. The results indicated that the antioxidant activity of LPPE was 231.350 +/- 21.640, 252.380 +/- 31.150, and 558.220 +/- 59.810 (mg Vc/g) as determined by DPPH, ABTS, and FRAP, respectively. UPLC-QqQ-MS/MS analysis indicated that the main compounds in LPPE were gallic acid, proanthocyanidin, epicatechin, and phlorizin. LPPE supplementation prevented the body weight gain and decreased serum and liver lipids in high-fat diet-induced-obese mice. Furthermore, RT-PCR and Western blot analysis indicated that LPPE upregulated the expression of PPAR alpha and LXR alpha and then regulated their target genes, including FAS, CYP7A1, and CYP27A1, which are involved in lipid homeostasis. Taken together, this study supports the concept that LPPE can be used as a dietary supplement in regulating lipid metabolism.
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