Three new naphthoquinone-based meroterpenoids from Streptomyces sp. HBERC-16614 with antibacterial activities
文献类型： 外文期刊
作者： Zhang, Ya-Ni 1 ; Liu, Man-Li 1 ; Liu, Fang 1 ; Zhang, Zhi-Gang 1 ; Wu, Zhao-Yuan 1 ; Shi, Li-Qiao 1 ; Wan, Zhong-Yi 1 ; Wang, Yue-Ying 1 ; Zhang, Fei 1 ; Wang, Kai-Mei 1 ; Fang, Wei 1 ;
作者机构： 1.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan, Peoples R China
2.Natl Plant Protect Microbial Germplasm Resource Ba, Wuhan, Peoples R China
关键词： Naphthoquinone-based meroterpenoids; spironaphthomeroterpenoid; naphthablins D and E; antibacterial activities
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：1.6； 五年影响因子：2.0 ）
ISSN： 1478-6419
年卷期： 2025 年
页码：
收录情况： SCI
摘要： Three new naphthoquinone-based meroterpenoids (1-3), including spironaphthomeroterpenoid (1), a novel naphthoquinone-based meroterpenoid with a rare [5, 6] spiro-ring skeleton, and naphthablins D and E (2-3), along with three known analogues (4-6) were isolated from Streptomyces sp. HBERC-16614. The structures of these compounds, including their absolute configurations, were established by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectrum. The antibacterial activities of compounds (1-6) were evaluated against Staphylococcus aureus, Streptococcus suis, and Escherichia coli. Among them, compound 1 demonstrated potent antibacterial activity against S. aureus, with a minimum inhibitory concentration (MIC) value of 3.13 mu g/mL.
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