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Genome-wide identification of endosialin family of C-type lectins in common carp (Cyprinus carpio) and their response following Aeromonas hydrophila infection

文献类型： 外文期刊

作者： Yu, Minghui 1 ; Chang, Songhuan 1 ; Xu, Jian 2 ; Zhang, Hanyuan 2 ; Jiang, Yanliang 2 ;

作者机构： 1.Shanghai Ocean Univ, Coll Fisheries & Life, Shanghai, Peoples R China

2.Chinese Acad Fishery Sci, Key Lab Aquat Genom, CAFS Key Lab Aquat Genom, Minist Agr & Rural Affairs, Beijing, Peoples R China

关键词： Endosialin family genes; C-type lectin; Common carp; Aeromonas hydrophila; Immune response

期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.605； 五年影响因子：3.833 ）

ISSN： 0145-305X

年卷期： 2022 年 129 卷

页码：

收录情况： SCI

摘要： The endosialin family is the group XIV of C-type lectin, regulating several processes involved in innate immunity and inflammation. Endosialin family genes have been extensively studied in human and mammals, however, rarely reported in teleost. In the present study, a set of 8 endosialin family genes was identified across the entire common carp genome. Functional domain and motif prediction and phylogenetic analysis supported their annotation and orthologies. Through examining gene copy number across several vertebrates, endosialin family genes were found have undergone gene duplication. Most of the endosialin family genes were ubiquitously expressed during common carp early developmental stages, and presented tissue-specific expression patterns in various healthy tissues, with relatively high expression in intestine, liver, gill, spleen and kidney, indicating their likely essential roles in maintaining homeostasis and host immune response. After Aeromonas hydrophila infection, gene thbd-1, thbd-2 and cd93-2 were significantly up-regulated at one or more timepoints in spleen and kidney, while gene cd248a-1, cd248a-2, cd248b-1, cd248b-2, and cd93-1 were significantly down-regulated. Taken together, all these results suggested that endosialin family genes were involved in host immune response to A. hydrophila infection in common carp, and provided fundamental genomic resources for better understanding the critical roles of endosialin family on the primary innate immune processes in teleost.

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