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In-depth transcriptome profiling of Cherry Valley duck lungs exposed to chronic heat stress

文献类型： 外文期刊

作者： Liu, Yi 1 ; Sun, Dongyue 3 ; Xu, Congcong 4 ; Liu, Xiaoyong 1 ; Tang, Min 1 ; Ying, Shijia 2 ;

作者机构： 1.Jiangsu Univ, Sch Life Sci, Zhenjiang, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Anim Sci, Nanjing, Peoples R China

3.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing, Peoples R China

4.Beijing Univ Agr, Coll Anim Sci & Technol, Beijing, Peoples R China

关键词： chronic heat stress; duck rearing; environmental temperature; high-throughput sequencing technology; ceRNA

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：2.6； 五年影响因子：3.1 ）

ISSN：

年卷期： 2024 年 11 卷

页码：

收录情况： SCI

摘要： Amidst rising global temperatures, chronic heat stress (CHS) is increasingly problematic for the poultry industry. While mammalian CHS responses are well-studied, avian-specific research is lacking. This study uses in-depth transcriptome sequencing to evaluate the pulmonary response of Cherry Valley ducks to CHS at ambient temperatures of 20 degrees C and a heat-stressed 29 degrees C. We detailed the CHS-induced gene expression changes, encompassing mRNAs, lncRNAs, and miRNAs. Through protein-protein interaction network analysis, we identified central genes involved in the heat stress response-TLR7, IGF1, MAP3K1, CIITA, LCP2, PRKCB, and PLCB2. Subsequent functional enrichment analysis of the differentially expressed genes and RNA targets revealed significant engagement in immune responses and regulatory processes. KEGG pathway analysis underscored crucial immune pathways, specifically those related to intestinal IgA production and Toll-like receptor signaling, as well as Salmonella infection and calcium signaling pathways. Importantly, we determined six miRNAs-miR-146, miR-217, miR-29a-3p, miR-10926, miR-146b-5p, and miR-17-1-3p-as potential key regulators within the ceRNA network. These findings enhance our comprehension of the physiological adaptation of ducks to CHS and may provide a foundation for developing strategies to improve duck production under thermal stress.

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