Astragalus Polysaccharide Modulates the Gut Microbiota and Metabolites of Patients with Type 2 Diabetes in an In Vitro Fermentation Model
文献类型： 外文期刊
作者： Zhang, Xin 1 ; Jia, Lina 1 ; Ma, Qian 1 ; Zhang, Xiaoyuan 3 ; Chen, Mian 3 ; Liu, Fei 3 ; Zhang, Tongcun 1 ; Jia, Weiguo 4 ; Zhu, Liying 5 ; Qi, Wei 1 ; Wang, Nan 1 ;
作者机构： 1.Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China
2.Minist Educ & Tianjin, Key Lab Ind Fermentat Microbiol, Tianjin 300457, Peoples R China
3.Shandong Acad Pharmaceut Sci, Key Lab Biopharmaceut, Engn Lab Polysaccharide Drugs, Natl Local Joint Engn Lab Polysaccharide Drugs,Pos, Jinan, Peoples R China
4.Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, Natl Clin Res Ctr Geriatr, Chengdu 610041, Peoples R China
5.Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou 310021, Peoples R China
关键词： Astragalus polysaccharide; type 2 diabetes mellitus; fecal microbiota; metabolites
期刊名称：NUTRIENTS （ 影响因子：4.8； 五年影响因子：5.8 ）
ISSN：
年卷期： 2024 年 16 卷 11 期
页码：
收录情况： SCI
摘要： This study investigated the effect of astragalus polysaccharide (APS, an ingredient with hypoglycemic function in a traditional Chinese herbal medicine) on gut microbiota and metabolites of type 2 diabetes mellitus (T2DM) patients using a simulated fermentation model in vitro. The main components of APS were isolated, purified, and structure characterized. APS fermentation was found to increase the abundance of Lactobacillus and Bifidobacterium and decrease the Escherichia-Shigella level in the fecal microbiota of T2DM patients. Apart from increasing propionic acid, APS also caused an increase in all-trans-retinoic acid and thiamine (both have antioxidant properties), with their enrichment in the KEGG pathway associated with thiamine metabolism, etc. Notably, APS could also enhance fecal antioxidant properties. Correlation analysis confirmed a significant positive correlation of Lactobacillus with thiamine and DPPH-clearance rate, suggesting the antioxidant activity of APS was related to its ability to enrich some specific bacteria and upregulate their metabolites.
- 相关文献
作者其他论文 更多>>
-
Stimuli-responsive biodegradable silica nanoparticles: From native structure designs to biological applications
作者：Qi, Qianhui;Wang, Wei;Shen, Qian;Geng, Jiaying;An, Weizhen;Wu, Qiong;Yu, Changmin;Shen, Qian;Geng, Jiaying;An, Weizhen;Wu, Qiong;Yu, Changmin;Qi, Qianhui;Yu, Changmin;Wang, Nan;Zhang, Yu;Li, Xue;Li, Lin
关键词：Biodegradation; Silica nanoparticles; Stimuli -responsive; Multiple frameworks; Biological applications
-
Ginkgo biloba Sex Identification Methods Using Hyperspectral Imaging and Machine Learning
作者：Chen, Mengyuan;Yang, Rui;Lu, Xiangyu;Liu, Fei;Lin, Chenfeng;Zhao, Yunpeng;Sun, Yongqi;Lou, Weidong;Deng, Xunfei
关键词：Ginkgo biloba; sex identification; leaf morphology; hyperspectral imaging; machine learning
-
Faecal hsa-miR-7704 inhibits the growth and adhesion of Bifidobacterium longum by suppressing ProB and aggravates hepatic encephalopathy
作者：Wang, Yuchong;Li, Yuyu;Lv, Longxian;Hong, Liang;Zhang, Yu;Diao, Hongyan;Zhu, Liying;Wang, Xin;Wang, Xueyao
关键词：
-
Multi-phenotype response and cadmium detection of rice stem under toxic cadmium exposure
作者：Wang, Wei;Wang, Leiping;Xiao, Hang;Wang, Wei;Man, Zun;Li, Xiaolong;Chen, Rongqin;Pan, Tiantian;Liu, Fei;Wang, Wei;Wang, Leiping;Xiao, Hang;Zhao, Yiying;Dai, Xiaorong
关键词：Rice stem; Cadmium; Plant phenotype; Lipid peroxidation; Laser-induced breakdown spectroscopy; Machine learning
-
3D-based precise evaluation pipeline for maize ear rot using multi-view stereo reconstruction and point cloud semantic segmentation
作者：Yang, Rui;He, Yong;Lu, Xiangyu;Liu, Fei;Zhao, Yiying;Li, Yanmei;Yang, Yinhui;Kong, Wenwen
关键词：Maize ear rot; Multi-view stereo reconstruction; Point cloud; 3D semantic segmentation; Deep learning
-
Exploring the mechanism of probiotics in enhancing the utilization of chemical components (or polyphenols) of grape seed extract
作者：Xu, Lei;Li, Xiaoqiong;Zhu, Liying;Wang, Xin;Li, Jinjun;Xu, Lei;Sun, Haibiao;Liao, Jiahao;Xu, Benhong;Li, Liang;Ze, Xiaolei
关键词：In vitro fermentation; Grape seed extract; Gut microbiota; Compound probiotics; High-performance liquid chromatography; 16S rRNA sequencing
-
Recent advances in the exploration and discovery of SARS-CoV-2 inhibitory peptides from edible animal proteins
作者：Kong, Xiaoyue;Liu, Xingquan;Kong, Xiaoyue;Wang, Wei;Bai, Kaiwen;Wu, Yi;Qi, Qianhui;Zhong, Yizhi;Xie, Junran;Wang, Nan;Zhang, Yu
关键词：efficacy; mechanisms; peptides derived from animal proteins; SARS-CoV-2; computer-aided design methods; drug delivery strategies
