Postbiotic Limosilactobacillus reuteri cultured with Polygonatum kingianum polysaccharides ameliorates high-fat-high-sugar-deteriorated colitis and associated hepatobiliary disorders
文献类型： 外文期刊
作者： Liu, Tianqi 1 ; Lv, Jiayao 1 ; Bian, Bo 2 ; Wu, Qingyang 2 ; Zhou, Lanqi 1 ; Zhang, Shiyi 1 ; Song, Wei 1 ; Li, Xiaoqiong 3 ; Tian, Honglei 1 ; Cheng, Ken 2 ; Shi, Lin 1 ;
作者机构： 1.Shaanxi Normal Univ, Sch Food Engn & Nutr Sci, Xian 710062, Peoples R China
2.Xian Jiaotong Liverpool Univ, Wisdom Lake Acad Pharm, Suzhou 215123, Peoples R China
3.Inst Food Sci, Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China
关键词： Postbiotics; Polygonatum kingianum; Limosilactobacillus reuteri; Gut dysbacteriosis; Gut-liver axis
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2025 年 322 卷
页码：
收录情况： SCI
摘要： Unhealthy diet exacerbates inflammatory bowel disease and its associated hepatic disruptions. The present study demonstrated the superior efficacy of the heat-inactivated Limosilactobacillus reuteri WX-94 (L. reuteri), cultured with Polygonatum kingianum polysaccharides (PKP postbiotic) in ameliorating a high-fat-high-sugar (HFHS)deteriorated colitis in rats, which outperforming PKP alone, its symbiotic form, and inactivated L. reuteri cultured without PKP. HFHS deteriorated liver functions in rats following a DSS administration, which were reversed by PKP postbiotic. PKP postbiotic exclusively enriched Prevotella and Lactobacillus while decreasing Escherichia.coil, along with the elevation in fecal short-chain fatty acids, serum bile acids (e.g., taurocholic acid, taurallocholic acid and tauroursocholic acid), indole derivatives (e.g., indolepropionic acid, indoleacetic acid, indolelactic acid) and phospholipids. Mechanistically, PKP postbiotic suppressed colonic inflammation and hepatobiliary disorders through regulating tryptophan catabolism-activated AHR/IL-22 signaling and bile acids-activated TLR4/NF kappa B/ NLRP3 signaling. Furthermore, we utilized human data sourced from Gene Expression Omnibus databases to confirm the involvement of key pathways regulated by PKP postbiotic in the colitis pathogenesis. Mendelian randomization-derived causal associations were observed between PKP postbiotic-elevated indole lactic acid with both colitis and nonalcoholic fatty liver disease. Our study presents compelling evidence of a novel property of PKP that augments the health-promoting benefits of inactivated L. reuteri.
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