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Sesquiterpenoids and Benzofuranoids from the Marine-Derived Fungus Aspergillus ustus 094102

文献类型： 外文期刊

作者： Lu, Zhenyu 2 ; Wang, Yi 2 ; Miao, Chengdu 1 ; Liu, Peipei 2 ; Hong, Kui 1 ; Zhu, Weiming 2 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biol Sci & Biotechnol, Haikou 571101, Peoples R China

2.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

关键词： Aspergillus;Bruguiera gymnorhiza;rhizosphere;sesquiterpenoids;chemical structure;stereochemistry;spectral analysis;medicinal properties;cytotoxicity;anticarcinogenic activity;human diseases;human health;China.;Aspergillus ustus;benzofuranoids;isochromane;ustusorane;ustusol;ustusolates;Internet resource.

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Eight drimane sesquiterpenes (1?8), six isochromane derivatives (9?14), and three known compounds, daldinin B (15), 9α-hydroxy-6β-[(2E,4E,6E)-octa-2,4,6-trienoyloxy]-5α-drim-7-en-11,12-olide (16), and pergillin (17), were isolated from the EtOAc extract of the marine-derived fungus Aspergillus ustus 094102. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxic effects on A549 and HL-60 cell lines were evaluated by SRB and MTT methods. Ustusorane E (13) showed significant cytotoxicity against HL-60 cells with an IC50 value of 0.13 μM. Ustusolates C (6) and E (8) exhibited moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 μM, respectively, and ustusolate A (4) showed weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 μM, respectively.

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