Bacillus lipopeptides inhibit lipase activity and promote 3T3-L1 preadipocyte differentiation
文献类型： 外文期刊
作者： Chen, Meichun 1 ; Chen, Deju 1 ; Xiao, Rongfeng 1 ; Zheng, Xuefang 1 ; Liu, Bo 1 ; Wang, Jieping 1 ;
作者机构： 1.Fujian Acad Agr Sci, Inst Resources Environm & Soil Fertilizer, Fuzhou 350003, Peoples R China
关键词： Lipopeptide; lipase inhibitory activity; PPAR gamma
期刊名称：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY （ 影响因子：5.4； 五年影响因子：4.9 ）
ISSN： 1475-6366
年卷期： 2024 年 39 卷 1 期
页码：
收录情况： SCI
摘要： Bacillus lipopeptides have been reported to display anti-obesity effects. In the present study, Lipopeptides from Bacillus velezensis FJAT-45028 that consisted of iturin, fengycin and surfactin were reported. The lipopeptides exhibited a strong lipase inhibition activity in a concentration-dependent manner with a half maximal inhibitory concentration of 0.012 mg/mL, and the inhibition mechanism and type were reversible and competitive, respectively. Results of CCK8 assay showed that 3T3-L1 preadipocyte cells were completely viable under treatment of 0.050-0.2 mg/mL lipopeptides for 24 or 48 h. It was found that the lipopeptides could increase lipid droplets in the differentiated 3T3-L1 adipocytes in tested concentration and suppress the expression of peroxisome proliferator-activated receptor gamma (PPAR gamma). These results indicated the potential anti-obesity mechanism of the tested lipopeptides might be to inhibit lipase activity but not to suppress lipid accumulation in the adipocytes. Moreover, the lipopeptides could elevate glucose utilisation by 14.43%-33.81% in the differentiated 3T3-L1 adipocytes.
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