Lipopeptide C17 Fengycin B Exhibits a Novel Antifungal Mechanism by Triggering Metacaspase-Dependent Apoptosis in Fusarium oxysporum
文献类型： 外文期刊
作者： Deng, Ying-jie 1 ; Chen, Zheng 4 ; Chen, Yan-ping 1 ; Wang, Jie-ping 1 ; Xiao, Rong-feng 1 ; Wang, Xun 2 ; Liu, Bo 1 ; Chen, Mei-chun 1 ; He, Jin 2 ;
作者机构： 1.Fujian Acad Agr Sci, Inst Resources Environm & Soil Fertilizer, Fuzhou 350003, Peoples R China
2.Huazhong Agr Univ, Natl Key Lab Agr Microbiol, Wuhan 430000, Hubei, Peoples R China
3.Huazhong Agr Univ, Coll Life Sci & Technol, Hubei Hongshan Lab, Wuhan 430000, Hubei, Peoples R China
4.Fujian Acad Agr Sci, Inst Plant Protect, Fuzhou 350003, Fujian, Peoples R China
关键词： Bacillus; lipopeptide; fengycin; pathogenic fungus; Fusarium oxysporum; cellapoptosis; metacaspase-dependent
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）
ISSN： 0021-8561
年卷期： 2024 年 72 卷 14 期
页码：
收录情况： SCI
摘要： Fusarium wilt is a worldwide soil-borne fungal disease caused by Fusarium oxysporum that causes serious damage to agricultural products. Therefore, preventing and treating fusarium wilt is of great significance. In this study, we purified ten single lipopeptide fengycin components from Bacillus subtilis FAJT-4 and found that C-17 fengycin B inhibited the growth of F. oxysporum FJAT-31362. We observed early apoptosis hallmarks, including reactive oxygen species accumulation, mitochondrial dysfunction, and phosphatidylserine externalization in C-17 fengycin B-treated F. oxysporum cells. Further data showed that C-17 fengycin B induces cell apoptosis in a metacaspase-dependent manner. Importantly, we found that the expression of autophagy-related genes in the TOR signaling pathway was significantly upregulated; simultaneously, the accumulation of acidic autophagy vacuoles in F. oxysporum cell indicated that the autophagy pathway was activated during apoptosis induced by C-17 fengycin B. Therefore, this study provides new insights into the antifungal mechanism of fengycin.
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