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Structural characterization and antitumor activity of a polysaccharide from Dendrobium wardianum

文献类型： 外文期刊

作者： Ye, Guangying 1 ; Li, Jie 1 ; Zhang, Jinhui 1 ; Liu, Hailin 1 ; Ye, Qingsheng 2 ; Wang, Zaihua 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Environm Hort Res Inst, Guangdong Prov Key Lab Ornamental Plant Germplasm, Guangzhou, Peoples R China

2.South China Normal Univ, Coll Life Sci, Guangdong Prov Key Lab Biotechnol Plant Dev, Guangzhou, Peoples R China

关键词： Dendrobium wardianum; Polysaccharide characteristics; Acetylated glucomannan lung cancer cells; Anti-tumour activity

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN： 0144-8617

年卷期： 2021 年 269 卷

页码：

收录情况： SCI

摘要： Through hot water extraction, protein removal and chromatographic purification, DWPP-Is was found to be the major polysaccharide present in the stem of D. wardianum. The Mn and Mw of DWPP-Is were 29.0 kDa and 98.6 kDa, respectively. Furthermore, mannose and glucose were found to be the most abundant monosaccharides in DWPP-Is. Their backbones consist of (1 -* 4)-beta-D-Glcp and O-acetylated (1 -* 4)-beta-D-Manp, which are similar to the structures of other anti-tumour Dendrobium polysaccharides. The inhibition rate of DWPP-Is treatment on SPC-A-1 cells (2 mg/mL, 72 h) reached 56.0%. Intragastric administration of DWPP-Is on A549 tumour-bearing KM mice (10 mg/mL, 0.2 mL) exhibited similar inhibition ratios to that of erlotinib hydrochloride (2 mg/mL). Moreover, the highest inhibition was observed in P-CK treatment combined with DWPP-Is, reaching an inhibition rate of 23.4%. These results suggest that DWPP-Is has the potential to be a functional agent for lung cancer prevention.

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