Structural characterization and antitumor activity of a polysaccharide from Dendrobium wardianum
文献类型: 外文期刊
作者: Ye, Guangying 1 ; Li, Jie 1 ; Zhang, Jinhui 1 ; Liu, Hailin 1 ; Ye, Qingsheng 2 ; Wang, Zaihua 1 ;
作者机构: 1.Guangdong Acad Agr Sci, Environm Hort Res Inst, Guangdong Prov Key Lab Ornamental Plant Germplasm, Guangzhou, Peoples R China
2.South China Normal Univ, Coll Life Sci, Guangdong Prov Key Lab Biotechnol Plant Dev, Guangzhou, Peoples R China
关键词: Dendrobium wardianum; Polysaccharide characteristics; Acetylated glucomannan lung cancer cells; Anti-tumour activity
期刊名称:CARBOHYDRATE POLYMERS ( 影响因子:9.381; 五年影响因子:8.678 )
ISSN: 0144-8617
年卷期: 2021 年 269 卷
页码:
收录情况: SCI
摘要: Through hot water extraction, protein removal and chromatographic purification, DWPP-Is was found to be the major polysaccharide present in the stem of D. wardianum. The Mn and Mw of DWPP-Is were 29.0 kDa and 98.6 kDa, respectively. Furthermore, mannose and glucose were found to be the most abundant monosaccharides in DWPP-Is. Their backbones consist of (1 -* 4)-beta-D-Glcp and O-acetylated (1 -* 4)-beta-D-Manp, which are similar to the structures of other anti-tumour Dendrobium polysaccharides. The inhibition rate of DWPP-Is treatment on SPC-A-1 cells (2 mg/mL, 72 h) reached 56.0%. Intragastric administration of DWPP-Is on A549 tumour-bearing KM mice (10 mg/mL, 0.2 mL) exhibited similar inhibition ratios to that of erlotinib hydrochloride (2 mg/mL). Moreover, the highest inhibition was observed in P-CK treatment combined with DWPP-Is, reaching an inhibition rate of 23.4%. These results suggest that DWPP-Is has the potential to be a functional agent for lung cancer prevention.
- 相关文献
作者其他论文 更多>>
-
Exploring the co-operativity of secretory structures for defense and pollination in flowering plants
作者:Li, Jinjin;Hu, Hao;Fu, Hansen;Zeng, Tuo;Li, Jiawen;Wang, Caiyun;Li, Jie;Wang, Manqun;Jongsma, Maarten A.
关键词:Terpenes; Glandular trichomes; Secretory duct; Flower defense; Flower pollination; Asteraceae; Pyrethrum
-
Effect of Black Tea Polysaccharides on Alleviating Type 2 Diabetes Mellitus by Regulating PI3K/Akt/GLUT2 Pathway
作者:Zhang, Zhenbiao;Deng, Xuming;Zhang, Lingzhi;Zhang, Zhenbiao;Chen, Ruohong;Li, Qiuhua;Sun, Lingli;Cao, Junxi;Lai, Zhaoxiang;Lai, Xingfei;Sun, Shili;Wang, Zaihua
关键词:black tea; tea polysaccharides; chemical property; hypoglycemic effect; PI3K-Akt
-
Exploring the interspecific relationships among Dendrobium species via electrochemical fingerprinting techniques
作者:Xia, Ke;Wu, Qiaofen;Chai, Shengfeng;Yang, Yanni;Liu, Qiao;Zhao, Zhiguo;Xiong, Zhongchen;Qiu, Shuo;Xia, Ke;Wu, Qiaofen;Chai, Shengfeng;Yang, Yanni;Liu, Qiao;Zhao, Zhiguo;Xiong, Zhongchen;Qiu, Shuo;Wang, Zaihua
关键词:Electro-chemotaxonomy; Voltammetric profiles; Cluster analysis; Phylogenetic relationships; Medicinal orchids
-
Potted Phalaenopsis Grading: Precise Bloom and Bud Counting with the PA-YOLO Algorithm and Multiviewpoint Imaging
作者:Yang, Yi;Zhang, Guankang;Ma, Shutao;Wang, Zaihua;Wang, Zaihua;Liu, Houcheng;Gu, Song;Gu, Song
关键词:flower counting; deep learning; multiple viewpoints; flower detection; potted Phalaenopsis; machine vision
-
Drought Stress Induced Different Response Mechanisms in Three Dendrobium Species under Different Photosynthetic Pathways
作者:Xia, Ke;Wu, Qiaofen;Yang, Yanni;Liu, Qiao;Zhao, Zhiguo;He, Jinxiang;Chai, Shengfeng;Qiu, Shuo;Wang, Zaihua;Li, Jie
关键词:carbon metabolism; drought tolerant; phosphoenolpyruvate carboxylase; enrichment analysis; Dendrobium
-
Phosphorylation of 399S at CsHsp70 of Cymbidium sinense is essential to maintain chlorophyll stability
作者:Gao, Jie;Lu, Chuqiao;Wei, Yonglu;Xie, Qi;Jin, Jianpeng;Li, Jie;Yang, Fengxi;Zhu, Genfa
关键词:Cymbidium sinense; Proteomics; Phosphoproteomics; Leaf variegation; Heat-shock protein 70
-
Isolation and characterization of a nephroprotective polysaccharide from Dendrobium chrysotoxum Lindl against LPS-induced acute kidney injury mice
作者:Hao, Yuting;Lao, Shenghui;Chen, Xiao;Liao, Wenzhen;Liu, Hailin;Ye, Guangying;Wang, Zaihua
关键词:Dendrobium Chrysotoxum Lindl; Polysaccharide; Structural characterization; AKI; Anti-inflammatory