Preliminarily curative effectiveness of long-term bitter melon Momordica charantia saponins administration for the glucose homeostasis of juvenile common carp (Cyprinus carpio) fed a high-starch diet
文献类型： 外文期刊
作者： Fan, Ze 1 ; Li, Jinnan 1 ; Wu, Di 1 ; Li, Chenhui 1 ; Cao, Dingchen 1 ; Miao, Linghong 2 ; Ge, Xianping 2 ; Wang, Liansheng 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Key Lab Aquat Anim Dis & Immune Technol Heilongjia, Harbin, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Minist Agr & Rural Affairs, Wuxi, Peoples R China
3.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin 150070, Peoples R China
4.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 320200, Peoples R China
关键词： Momordica charantia saponins; High-starch diet; Insulin resistance; Glucose homeostasis; Hepatopancreas; Common carp
期刊名称：AQUACULTURE REPORTS （ 影响因子：3.385； 五年影响因子：3.645 ）
ISSN： 2352-5134
年卷期： 2022 年 25 卷
页码：
收录情况： SCI
摘要： Momordica charantia saponins (MCS) was supplemented to a high-starch diet to ssess the effect on the growth performance, glucose homeostasis modulating factors concerning the attenuated hyperglycemia, hyperlipemia and insulin resistance. Five iso-nitrogenous (30.48%) and isolipidic (5.41%) diets were formulated containing 30% starch (control group, HS), and were supplemented with 100 mg/kg (HS-MCS100), 400 mg/kg (HS-MCS400), 1600 mg/kg (HS-MCS1600) and 6400 mg/kg (HS-MCS6400) MCS on the basis of the HS diet. 450 common carp weighing (6.43 +/- 0.02) g were randomly divided into 5 groups, with three replicates in each group and 30 fish in each replicate. Results revealed that dietary MCS effectively enhanced the growth and feed efficiency and significantly attenuated the glucose homeostasis and insulin resistance triggered by the HS diet. Moreover, 1600 mg/kg of MCS administration fulfilled more efficient and significant improvement of weight gain rate (WGR), specific growth rate (SGR), feed conversion rate (FCR), protein efficiency ratio (PER), protein and lipid deposition in the whole body. Alterations of serum biochemical indices revealed that 1600 mg/kg of MCS administration remarkably suppressed the hyperglycemia and hyperlipemia and elevated the insulin sensitivity. Enzyme activity and gene expression analysis of glycometabolism indicated that 1600 mg/kg of MCS administration could attenuate the hepatopancreas insulin resistance by enhancing glycolysis ability, promoting the glycogen synthesis and inhibiting the gluconeogenesis through activating PI3K/AKT signaling pathway. On all accounts detail, appropriate MCS administration have potential value in the alleviation of insulin resistance, thereby effectually maintain the glucose homeostasis and giving play to growth promoting effect for common carp fed with a high-carbohydrate diet.
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