文献类型： 外文期刊
作者： Zhong, Liqiao 1 ; Wu, Luyin 1 ; Ru, Huijun 1 ; Wei, Nian 1 ; Yao, Fan 1 ; Zhang, He 3 ; Ni, Zhaohui 1 ; Duan, Xinbin 1 ; Li, Yunfeng 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Fishery Resources & Environm Sci Expt Stn Uppermid, Minist Agr & Rural Affairs, Wuhan 430223, Peoples R China
2.Sun Yat sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Pollu, Sch Publ Hlth, Dept Occupat & Environm Hlth, Guangzhou 510080, Peoples R China
3.Wenzhou Univ, Coll Life & Environm Sci, Natl & Local Joint Engn Res Ctr Ecol Treatment Tec, Zhejiang Prov Key Lab Subtrop Water Environm & Mar, Wenzhou 325035, Peoples R China
关键词： Phenanthrene; Adult zebrafish; Thyroid disruption; Hypothalamic-pituitary-thyroid axis; Sex-specific
期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：4.52； 五年影响因子：4.203 ）
ISSN： 1532-0456
年卷期： 2023 年 263 卷
页码：
收录情况： SCI
摘要： Polycyclic aromatic hydrocarbons (PAHs) are well-known contaminants with widespread distribution in envi-ronment and food. Phenanthrene is one of the most abundant PAHs in food and aquatic environment and generates reproductive and developmental toxicity in zebrafish. Nonetheless, whether phenanthrene caused sex -specific thyroid disruption in adult zebrafish is unclear. To determine this, adult zebrafish (male and female) were treated with phenanthrene (0, 0.85, 8.5, and 85 mu g/L) for 60 days. After the treatment period, we assessed the concentrations of thyroid hormones (THs) and expression levels of genes in the hypothalamic-pituitary -thyroid (HPT) axis. The results showed that phenanthrene exposure can lead to thyroid disruption in both male and female zebrafish. Exposure to phenanthrene dramatically reduced the levels of L-thyroxine (T4) and L-triiodothyronine (T3) in both male and female zebrafish, with a similar trend in both. However, the genes expression profiles of hypothalamic-pituitary-thyroid (HPT) axis were sex-specific. In all, the present study demonstrated that phenanthrene exposure could result in sex-specific thyroid disruption in adult zebrafish.
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