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Comparison of viral communities in the blood, feces and various tissues of wild brown rats (Rattus norvegicus)

文献类型： 外文期刊

作者： Zhuang, Zi 1 ; Qian, Lingling 1 ; Lu, Juan 1 ; Zhang, Xiaodan 2 ; Mahmood, Asif 1 ; Cui, Lei 3 ; Wang, Huiying 4 ; Wang, Xiaochun 1 ; Yang, Shixing 1 ; Ji, Likai 1 ; Shan, Tongling 4 ; Shen, Quan 1 ; Zhang, Wen 1 ;

作者机构： 1.Jiangsu Univ, Sch Med, Dept Lab Med, Zhenjiang 212013, Peoples R China

2.Zhenjiang Ctr Dis Prevent & Control, Dept Clin Lab, Zhenjiang 212002, Peoples R China

3.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, Shanghai 200062, Peoples R China

4.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Dept Swine Infect Dis, Shanghai 200241, Peoples R China

5.Jiangsu Univ, Zhenjiang, Peoples R China

关键词： Wild Rattus norvegicus; Viral metagenomics; Virome; Zhenjiang

期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）

ISSN：

年卷期： 2023 年 9 卷 6 期

页码：

收录情况： SCI

摘要： Viral diseases caused by new outbreaks of viral infections pose a serious threat to human health. Wild brown rats (Rattus norvegicus), considered one of the world's largest and most widely distributed rodents, are host to various zoonotic pathogens. To further understand the compo-sition of the virus community in wild brown rats and explore new types of potentially pathogenic viruses, viral metagenomics was conducted to investigate blood, feces, and various tissues of wild brown rats captured from Zhenjiang, China. Results indicated that the composition of the virus community in different samples showed significant differences. In blood and tissue samples, members of the Parvoviridae and Anelloviridae form the main body of the virus community. Picornaviridae, Picobirnaviridae, and Astroviridae made up a large proportion of fecal samples. Several novel genome sequences from members of different families, including Anelloviridae, Parvoviridae, and CRESS DNA viruses, were detected in both blood and other samples, suggesting that they have the potential to spread across organs to cause viremia. These viruses included not only strains closely related to human viruses, but also a potential recombinant virus. Multiple dual-segment picornaviruses were obtained from fecal samples, as well as virus sequences from the Astroviridae and Picornaviridae. Phylogenetic analysis showed that these viruses belonged to different genera, with multiple viruses clustered with other animal viruses. Whether they have pathogenicity and the ability to spread across species needs further study.

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