Bisabolane-type sesquiterpenoids and bacillibactin from the marine-derived fungus Aspergillus sydowii SCSIO 41041 and their enzyme inhibiting activity
文献类型： 外文期刊
作者： Song, Ying-Ying 1 ; Liu, Qing-Xia 3 ; Pang, Xiao-Yan 1 ; Chen, Zhi-Yun 1 ; Huang, Hong-Hui 3 ; Wang, Jun-Feng 1 ; Liu, Yong-Hong 1 ;
作者机构： 1.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Guangdong Prov Key Lab Fishery Ecol & Environm, Guangzhou, Peoples R China
4.Sanya Inst Ocean Ecoenvironm Engn, Yazhou Sci Bay, Sanya, Peoples R China
关键词： Creseis acicula; Aspergillus sydowii; anti-neuraminidase activity
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.2； 五年影响因子：2.3 ）
ISSN： 1478-6419
年卷期： 2023 年
页码：
收录情况： SCI
摘要： Twelve compounds, including eleven bisabolane-type sesquiterpenoids (1 - 11), and one bacillibactin (12) were identified from marine-derived fungus Aspergillus sydowii SCSIO 41041 isolated from Creseis acicula. The chemical structures were elucidated by the basis of spectroscopic evidences, including HRESIMS, NMR and optical rotation. Biologically, all compounds were evaluated for their acetyl cholin-esterase (AChE) enzyme, pancreatic lipase (PL) enzyme, neuraminidase (NA) and phosphodiesterase 4 (PDE4) inhibitory activities. Compound 12 displayed significant inhibitory activity against neuraminidase (NA) with an IC50 value of 24.0 mu M, which was equivalent to the positive drug oseltamivir phosphate (IC50 value of 20.0 mu M). And the NA inhibitory activity was confirmed by molecular docking analysis.
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