文献类型： 外文期刊
作者： Ou, Lanxin 1 ; Ye, Bijin 1 ; Sun, Mingfei 1 ; Qi, Nanshan 1 ; Li, Juan 1 ; Lv, Minna 1 ; Lin, Xuhui 1 ; Cai, Haiming 1 ; Hu, Junjing 1 ; Song, Yongle 1 ; Chen, Xiangjie 1 ; Zhu, Yibin 1 ; Yin, Lijun 1 ; Zhang, Jianfei 1 ; Liao, Shenquan 1 ; Zhang, Haoji 2 ;
作者机构： 1.Guangdong Acad Agr Sci, Key Lab Livestock Dis Prevent Guangdong Prov, Key Lab Avian Influenza & Other Major Poultry Dis, Inst Anim Hlth,Minist Agr & Rural Affairs, Guangzhou 510640, Peoples R China
2.Foshan Univ, Coll Life Sci & Engn, Foshan 528225, Peoples R China
关键词： Clostridium perfringens; Intestinal epithelial cell; Toxin; Tight junction; Cell death; Inflammation
期刊名称：ANAEROBE （ 影响因子：2.3； 五年影响因子：2.9 ）
ISSN： 1075-9964
年卷期： 2024 年 87 卷
页码：
收录情况： SCI
摘要： Clostridium perfringens , a Gram -positive bacterium, causes intestinal diseases in humans and livestock through its toxins, related to alpha toxin (CPA), beta toxin (CPB), C. perfringens enterotoxin (CPE), epsilon toxin (ETX), Iota toxin (ITX), and necrotic enteritis B -like toxin (NetB). These toxins disrupt intestinal barrier, leading to various cell death mechanisms such as necrosis, apoptosis, and necroptosis. Additionally, non-toxin factors like adhesins and degradative enzymes contribute to virulence by enhancing colonization and survival of C. perfringens . A vicious cycle of intestinal barrier breach, misregulated cell death, and subsequent inflammation is at the heart of chronic inflammatory and infectious gastrointestinal diseases. Understanding these mechanisms is essential for developing targeted therapies against C. perfringens -associated intestinal diseases.
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